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Table 4 Serum metabolomics summary

From: Microbiome function underpins the efficacy of a fiber-supplemented dietary intervention in dogs with chronic large bowel diarrhea

Metabolite Classification MANOVA P-value Change vs Baseline
Amino acids < 0.0001c Mixed
Carbohydrates 0.002c Mixed
Collagen metabolism < 0.0001c Mixed
Free fatty acids Eicosanoids 0.01a Mixed
Polyunsaturated n3 < 0.0001a Increased
Polyunsaturated n6 < 0.0001a Decreased
Saturated & monounsaturated < 0.0001a Mixed
Phospholipids Lysophospholipids < 0.0001c Mixed
Phosphatidylcholines (PC) < 0.0001c Mixed
Phosphatidylethanolamines (PE) 0.005c Mixed
Phosphatidylinositol (PI) < 0.0001a Mixed
Sphingolipids All < 0.0001a Decreased
Ceramides 0.01c Decreased
Dihydroceramides 0.03a Mixed
Dihydrosphingomyelins < 0.0001a Mixed
Hexosylceramides (HCER) 0.007a Decreased
Lactosylceramides (LCER) 0.02c Mixed
Sphingolipid synthesis ns  
Sphingosines ns  
Sphingomyelins 0.03c Mixed
Tocopherol metabolism 0.002c Mixed
Tryptophan indole pathway 0.02c Increased
  1. aLinear trend over days, bquadratic trend over days, ccubic trend over days, ns = not significant, mixed directionality varied depending upon the metabolites in the group