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Table 5 Exclusion of patients with other known causes for KCS

From: Topical applications of allogeneic adipose-derived mesenchymal stem cells ameliorate the canine keratoconjunctivitis sicca

Causes of KCS

Considerations in the diagnostic process

Congenital

onset of clinical signs less than 6-month-old

STT ≤ 5 mm/min

absence of other known causes of KCS

lack of response to topical immunosuppressant

Metabolic

Blood exam/clinical signs

Infectious

History/PCR/blood exam/biopsy

Drug induced

History

Neurogenic

Physical exam (ipsilateral dry nose) Neurological exam(±facial paralysis, Horner’s syndrome)

Iatrogenic

History