Time (h) | Saline | Codeine 0.3 mg/kg PO (n = 7) | Codeine 0.6 mg/kg PO (n = 7) | Codeine 1.2 mg/kg PO (n = 7) | Morphine 0.2 mg/kg IV (n = 7) |
---|---|---|---|---|---|
Baseline | 2.7 ± 0.8 | 2.7 ± 8 | 1.7 ± 0.5 | 2.4 ± 1.3 | 2.4 ± 1.5 |
0.5 | 3.4 ± 1.5 | 3.0 ± 0.8 | 2.3 ± 1.0 | 2.6 ± 0.8 | 1.4 ± 1.4 |
0.75 | 3.4 ± 1.3 | 3.0 ± 0.6 | 1.9 ± 0.7 | 2.0 ± 0.6 | 1.9 ± 1.7 |
1 | 3.1 ± 1.3 | 2.7 ± 1.8 | 2.6 ± 0.8 | 1.7 ± 0.8 | 1.6 ± 0.5 |
2 | 3.9 ± 0.7* | 2.9 ± 0.7 | 2.7 ± 1.0 | 2.4 ± 0.8 | 2.1 ± 1.3 |
4 | 3.9 ± 0.7* | 3.6 ± 1.0 | 4.0 ± 0.8* | 3.4 ± 0.8 | 3.9 ± 1.1* |
6 | 3.7 ± 1.0* | 3.3 ± 0.8 | 3.4 ± 0.8* | 3.4 ± 1.1 | 3.4 ± 1.4 |
24 | – | 4.0 ± 0.8* | 3.3 ± 1.7* | 3.0 ± 1.5 | 3.3 ± 0.5 |