Table 2 Pharmacokinetic parameters (geometric mean or median (Tmax) and range) for codeine following a single oral administration of codeine (0.3, 0.6 and 1.2 mg/kg) to adult horses. All values reported were generated using non-compartmental analysis

C_max ng/mL

266.0 (91.2–415.4)

242.8 (132.1–551.0)

347.8 (125.4–693.0)

T_max (h)

0.5 (0.16–1.0)

0.5 (0.5–0.75)

0.5 (0.25–1.0)

Lambda_z(1/h)

0.345 (0.178–0.695)

0.328 (0.151–0.654)

0.252 (0.130–0.418)

HL Lambda_z (h)^*

1.84 (1.00–3.90)

1.94 (1.06–4.59)

2.60 (1.66–5.32)

AUC_0-inf (h*ng/mL)

295.4 (157.1–456.3)

308.7 (185.7–502.2)

457.6 (189.0–934.6)