Table 1 Table of GWAS results for 7 candidate SNPs sorted by the highest P-value. P-value, unadjusted P-value; P-value_BH, P-value adjusted according to Benjamini-Hochberg correction; CHR, chromosome; SNP, single nucleotide polymorphism; BP, genomic position (base-pair); A1, minor allele; F_A, frequency of minor allele in long-lived group; F_U, frequency of minor allele in reference group; A2, major allele; CHISQ, basic allelic chi-square test; OR, estimated odds ratio
From: Four novel genes associated with longevity found in Cane corso purebred dogs
Gene | P-value | P-value_BH | Position | CHR | SNP | BP | A1 | F_A | F_U | A2 | CHISQ | OR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
TDRP | 3.705e-07 | 0.01006 | 3’UTR | 25 | BICF2P365740 | 37,486,799 | T | 0.7222 | 0.03333 | C | 25.84 | 75.4 |
MC2R | 2.772e-05 | 0.09404 | intron | 1 | BICF2P1140956 | 24,364,734 | G | 0.7778 | 0.1667 | A | 17.57 | 17.5 |
NGDN | 3.969e-05 | 0.09404 | intron | 8 | BICF2P384545 | 3,705,090 | C | 0.6111 | 0.06667 | T | 16.89 | 22 |
RARB | 3.969e-05 | 0.09404 | intron | 23 | BICF2G630382633 | 18,647,529 | C | 0.6111 | 0.06667 | T | 16.89 | 22 |
FBXO25 | 6.334e-05 | 0.138 | intron | 25 | BICF2P999174 | 37,425,075 | A | 0.4444 | 0 | G | 16 | NA |
FBXL21 | 1.478e-04 | 0.1766 | exon | 11 | chr11_23,852,542 | 23,852,542 | T | 0.6667 | 0.1333 | C | 14.4 | 13 |
PARP9 | 3.413e-04 | 0.2636 | exon | 33 | chr33_25,671,811 | 25,671,811 | A | 0.7222 | 0.2 | C | 12.83 | 10.4 |