Parameter | Sampling time | Control | Test | Statistical analysis | |||
---|---|---|---|---|---|---|---|
Mean | 95% CI | Mean | 95% CI | Diff. within Test diet | Diff. between diets† | ||
Red blood cell count (RBC) (1012/L) 6-9 | Baseline | 5.86 | (5.60, 6.13) | 5.82 | (5.58, 6.06) | – | – |
Day 3 | 6.09* | (5.82, 6.37) | 5.74 | (5.50, 5.98) | NS | 0.034 | |
Day 14 | 5.97 | (5.71, 6.24) | 5.63* | (5.40, 5.86) | 0.049 | 0.036 | |
Day 28 | 5.86 | (5.60, 6.13) | 5.37* | (5.15, 5.59) | < 0.001 | < 0.001 | |
Hematocrit (HCT) (%) 40-55 | Baseline | 45.1 | (43.1, 47.1) | 44.8 | (43.0, 46.6) | – | – |
Day 3 | 45.7 | (43.7, 47.7) | 43.4* | (41.6, 45.1) | 0.035 | NS | |
Day 14 | 45.3 | (43.4, 47.3) | 42.6* | (40.9, 44.3) | < 0.001 | 0.011 | |
Day 28 | 45.3 | (43.3, 47.3) | 41.1* | (39.5, 42.8) | < 0.001 | < 0.001 | |
Total hemoglobin (HGB) (g/dL) 12-19 | Baseline | 15.9 | (15.2, 16.7) | 15.8 | (15.1, 16.4) | – | – |
Day 3 | 16.6* | (15.8, 17.3) | 15.8 | (15.1, 16.5) | NS | NS | |
Day 14 | 16.2 | (15.5, 17.0) | 15.3 | (14.7, 15.9) | NS | NS | |
Day 28 | 16.4 | (15.7, 17.2) | 14.8* | (14.2, 15.4) | < 0.001 | < 0.001 | |
Mean cell volume (MCV) (fL) 60-77 | Baseline | 76.9 | (75.4, 78.4) | 77.0 | (75.6, 78.4) | – | – |
Day 3 | 75.1* | (73.6, 76.6) | 75.6* | (74.2, 77.0) | < 0.001 | NS | |
Day 14 | 75.9* | (74.4, 77.4) | 75.7* | (74.3, 77.1) | < 0.001 | NS | |
Day 28 | 77.3 | (75.8, 78.8) | 76.6 | (75.2, 78.0) | NS | NS | |
Mean cell hemoglobin (MCH) (pg) 17-23 | Baseline | 27.2 | (26.5, 27.9) | 27.1 | (26.5, 27.7) | – | – |
Day 3 | 27.2 | (26.6, 27.9) | 27.5 | (26.9, 28.2) | NS | NS | |
Day 14 | 27.2 | (26.5, 27.8) | 27.2 | (26.6, 27.8) | NS | NS | |
Day 28 | 28.0* | (27.3, 28.7) | 27.5 | (26.9, 28.1) | NS | NS | |
Mean cell hemoglobin concentra-tion (MCHC) (g/dL) 31-34 | Baseline | 35.4 | (34.7, 36.0) | 35.2 | (34.6, 35.8) | – | – |
Day 3 | 36.2* | (35.6, 36.9) | 36.4* | (35.9, 37.0) | < 0.001 | NS | |
Day 14 | 35.8 | (35.2, 36.4) | 35.9* | (35.4, 36.5) | 0.023 | NS | |
Day 28 | 36.2* | (35.6, 36.8) | 35.9* | (35.4, 36.5) | 0.021 | NS | |
Red cell distribution width (RDW) (%) 14-17 | Baseline | 13.3 | (12.7, 13.9) | 13.7 | (13.1, 14.3) | – | – |
Day 3 | 14.0* | (13.3, 14.6) | 13.6 | (13.0, 14.2) | NS | 0.003 | |
Day 14 | 14.4* | (13.8, 15.1) | 13.8 | (13.2, 14.3) | NS | < 0.001 | |
Day 28 | 14.2* | (13.6, 14.9) | 13.6 | (13.0, 14.2) | NS | < 0.001 | |
White blood cell count (WBC) (109/L) 6-12 | Baseline | 5.40 | (4.25, 6.85) | 5.41 | (4.35, 6.72) | – | – |
Day 3 | 6.28* | (4.95, 7.97) | 5.35 | (4.30, 6.65) | NS | 0.049 | |
Day 14 | 5.85 | (4.61, 7.43) | 5.79 | (4.66, 7.20) | NS | NS | |
Day 28 | 6.01 | (4.73, 7.63) | 5.53 | (4.45, 6.87) | NS | NS | |
Lymphocyte count (109/L) 1.2-3.2 | Baseline | 1.44 | (1.17, 1.71) | 1.36 | (1.17, 1.71) | – | – |
Day 3 | 1.60 | (1.33, 1.87) | 1.46 | (1.17, 1.71) | NS | NS | |
Day 14 | 1.41 | (1.14, 1.68) | 1.43 | (1.17, 1.71) | NS | NS | |
Day 28 | 1.66 | (1.39, 1.93) | 1.42 | (1.17, 1.71) | NS | NS | |
Monocyte count (109/L) 0.3-0.8 | Baseline | 0.55 | (0.43, 0.67) | 0.53 | (0.42, 0.64) | – | – |
Day 3 | 0.61 | (0.49, 0.73) | 0.60* | (0.49, 0.71) | 0.044 | NS | |
Day 14 | 0.60 | (0.48, 0.72) | 0.57 | (0.46, 0.68) | NS | NS | |
Day 28 | 0.64* | (0.52, 0.76) | 0.58 | (0.47, 0.69) | NS | NS | |
Eosinophil count (109/L) 1.2-6.8 | Baseline | 3.46 | (2.51, 4.78) | 3.50 | (2.61, 4.70) | – | – |
Day 3 | 3.98 | (2.89, 5.50) | 3.28 | (2.45, 4.41) | NS | NS | |
Day 14 | 3.80 | (2.75, 5.24) | 3.79 | (2.83, 5.09) | NS | NS | |
Day 28 | 3.62 | (2.62, 5.00) | 3.52 | (2.63, 4.73) | NS | NS | |
Platelet count (PLT) (109/L) 150-500 | Baseline | 218 | (180, 255) | 186 | (151, 220) | – | – |
Day 3 | 201 | (164, 239) | 188 | (154, 222) | NS | NS | |
Day 14 | 211 | (174, 249) | 173 | (139, 208) | NS | NS | |
Day 28 | 199 | (162, 237) | 159 | (124, 193) | NS | NS | |
Mean platelet volume (MPV) (mm3) 6.7-11.1 | Baseline | 7.35 | (6.54, 8.16) | 7.77 | (7.03, 8.50) | – | – |
Day 3 | 7.30 | (6.49, 8.11) | 8.07 | (7.33, 8.80) | NS | NS | |
Day 14 | 7.34 | (6.53, 8.15) | 8.52* | (7.79, 9.26) | < 0.001 | < 0.001 | |
Day 28 | 7.31 | (6.50, 8.12) | 8.63* | (7.90, 9.37) | < 0.001 | < 0.001 |