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Table 2 Multivariable model results displaying the association for drug groups (A) and individual drugs (B)

From: The effects of oclacitinib treatment on antimicrobial usage in allergic dogs in primary practice: an Australia wide case-control study

Model A B
Variable OR (95% CI) P-value* OR (95% CI) P-value*
Age   < 0.001   < 0.001
1 to 4 years Reference   Reference  
 > 4 to 8 years 0.84 (0.72–0.97) 0.019 0.84 (0.73–0.96) 0.013
 > 8 years 0.5 (0.42–0.6) < 0.001 0.53 (0.45–0.63) < 0.001
Sex
 Male Reference   Reference  
 Female 0.96 (0.83–1.1) 0.535 0.95 (0.83–1.09) 0.453
Neuter Status
 Neutered Reference   Reference  
 Entire 0.64 (0.52–0.78) < 0.001 0.66 (0.54–0.81) < 0.001
Breeds   < 0.001   < 0.001
 Small Reference   Reference  
 Medium 0.53 (0.43–0.64) < 0.001 0.53 (0.43–0.64) < 0.001
 Large 0.46 (0.39–0.55) < 0.001 0.48 (0.4–0.56) < 0.001
Evidence of concurrent skin infection at baseline   < 0.001   < 0.001
 Non-infectious allergic dermatitis Reference   Reference  
 No evidence of concurrent skin infection 0.73 (0.5–1.06) 0.094 0.74 (0.52–1.06) 0.099
 Superficial pyoderma 2.71 (1.89–3.89) < 0.001 2.58 (1.81–3.68) < 0.001
 Deep pyoderma Omitted   Omitted  
Infectious agents in ear at baseline   0.073   0.16
 No infectious agents present Reference   Reference  
 Cocci present 0.99 (0.65–1.51) 0.965 0.91 (0.59–1.41) 0.687
 Rods present 0.53 (0.18–1.55) 0.248 0.52 (0.17–1.56) 0.244
Malassezia present 1.31 (1.02–1.69) 0.035 1.23 (0.98–1.56) 0.076
Total number of courses
 Topical glucocorticoids 0.78 (0.62–0.98) 0.034   
 Systemic glucocorticoids 0.5 (0.39–0.64) 0   
 Antihistamines 0.48 (0.31–0.74) 0.001   
Other
 Allergy testing (yes/no) 3.94 (1.27–12.18) 0.017   
 Hypoallergenic diet 1.77 (1.26–2.47) 0.001   
 Medicated shampoo 0.69 (0.51–0.92) 0.011   
Total number of courses for individual antimicrobial drug
 Cefovecin    0.62 (0.39–0.98) 0.043
 Chlorhexidine (2–5%)    0.57 (0.42–0.77) < 0.001
 Neomycin    0.4 (0.28–0.56) < 0.001
 Amoxycillin plus clavulanic acid    0.55 (0.39–0.78) 0.001
  1. *P values are significant at the 0.05 level. The P values for the individual levels of the categorical variables compared to the baseline are given, with a bolded P value for all levels of that categorical variable combined