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Table 3 Mean ± standard deviation values of arterial blood gas analyses in dogs treated with ketamine (GK: bolus 0.5 mg kg−1; CRI 20 µg kg−1 min−1 in intra- and postoperative periods), fentanyl (GF: bolus 5 µg kg−1; intraoperative CRI 5 µg kg−1 h−1 and postoperative CRI 2 µg kg−1 h−1), or combination of ketamine-fentanyl (GKF: aforementioned doses) in intraoperative and postoperative period

From: Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy

  Anesthesia (minutes) Postoperative (hours)
Variable Group 20 40 60 80 1 4 8
pH GK 7.30 ± 0.08 7.29 ± 0.07 7.29 ± 0.06 7.31 ± 0.06 7.33 ± 0.04 7.39 ± 0.02 7.38 ± 0.04
GKF 7.36 ± 0.06 7.33 ± 0.06 7.31 ± 0.05 7.27 ± 0.04# 7.34 ± 0.02 7.38 ± 0.03 7.41 ± 0.01
GF 7.29 ± 0.08 7.27 ± 0.04# 7.27 ± 0.03# 7.25 ± 0.02# 7.33 ± 0.01 7.37 ± 0.02 7.41 ± 0.01
PaO2
(mmHg)
GK 294.6 ± 89.2 319.8 ± 80.2 304.4 ± 88.0 293.5 ± 4.4 80.4 ± 3.0 90.8 ± 13.9 83.7 ± 7.9
GKF 300.9 ± 62.3 328.1 ± 106.2 296.2 ± 89.8 290.3 ± 89.8 78.2 ± 6.6 79.4 ± 5.6 80.7 ± 6.3
GF 291.5 ± 4.07 274.2 ± 36.1 266.5 ± 29.0 282.7 ± 88.9 80.8 ± 3.1# 84.3 ± 5.0# 84.2 ± 5.4#
PaCO2 (mmHg) GK 45.9 ± 11.2 46.4 ± 10.2 45.2 ± 8.5 42.9 ± 6.3 40.9 ± 4.2 31.4 ± 1.7 32.3 ± 1.5
GKF 38.7 ± 6.1 40.6 ± 6.9 43.0 ± 5.8 48.5 ± 8.5# 43.3 ± 4.3 36.3 ± 2.0 33.1 ± 2.1
GF 44.2 ± 15.3 44.6 ± 8.8 43.3 ± 6.9 46.8 ± 5.3 41.5 ± 2.2 34.3 ± 3.9 35.3 ± 1.1
HCO3 (mmol L−1) GK 21.8 ± 1.8 21.3 ± 1.3 20.8 ± 1.5 20.9 ± 0.8 21.1 ± 2.0 18.6 ± 0.4 18.6 ± 0.7
GKF 21.0 ± 0.5 20.9 ± 0.7 20.8 ± 0.8 21.8 ± 1.7 23.2 ± 1.2 21.1 ± 1.2 20.3 ± 1.2
GF 7.30 ± 0.08 20.8 ± 3.0 20.1 ± 2.5 20.6 ± 2.4 21.0 ± 0.7 19.7 ± 2.6 21.2 ± 0.3
  1. # Significant difference in treatment with a basal time point. pH; arterial partial pressure of oxygen (PaCO2); arterial partial pressure of carbon dioxide (PaCO2); arterial bicarbonate (HCO3)