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Table 2 Mean ± standard deviation values of cardiorespiratory parameters, in dogs treated with ketamine (GK: bolus 0.5 mg kg−1; CRI 20 µg kg−1 min−1 in intra- and postoperative periods), fentanyl (GF: bolus 5 µg kg−1; intraoperative CRI 5 µg kg−1 h−1 and postoperative CRI 2 µg kg−1 h−1), or combination of ketamine-fentanyl (GKF: aforementioned doses) in postoperative period

From: Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy

 

Postoperative period (hours)

Variable

Group

Baseline

0.25

0.5

1

2

4

6

8

12

HR

(beats minute−1)

GK

104 ± 13

107 ± 14a

96 ± 20

87 ± 10a#

95 ± 14a

86 ± 13

86 ± 13

98 ± 39

101 ± 14

GKF

110 ± 22

104 ± 13a

97 ± 9

89 ± 7a

87 ± 14a.b#

90 ± 13

90 ± 7

95 ± 14

94 ± 16

GF

97 ± 35

82 ± 24b

71 ± 13

70 ± 20b#

75 ± 21#

65 ± 17#

79 ± 14

83 ± 18

83 ± 17

fR

(breaths minute−1)

GK

30 ± 10

40 ± 23

36 ± 15

43 ± 12#

47 ± 11#

37 ± 18

32 ± 10

30 ± 10

43 ± 47

GKF

34 ± 14

44 ± 41

39 ± 23

45 ± 23

52 ± 39

35 ± 13

36 ± 11

29 ± 10

35 ± 15

GF

28 ± 4

54 ± 21

44 ± 25

68 ± 37

43 ± 27

29 ± 17

33 ± 20

38 ± 19

27 ± 7

SAP

mmHg

GK

136 ± 25

137 ± 9a.b

139 ± 12

136 ± 15

136 ± 24

148 ± 17

144 ± 17

140 ± 22

143 ± 16

GKF

153 ± 13

153 ± 15a

155 ± 18

151 ± 17

170 ± 28

160 ± 15

160 ± 21

151 ± 12

143 ± 21

GF

136 ± 13

132 ± 23b

163 ± 12

148 ± 8

138 ± 35

136 ± 15

141 ± 10

158 ± 7#

147 ± 3

  1. a, b, c Significant difference between group. # Significant difference in treatment with a basal time point. HR Heart rate, fR respiratory rate, SAP systolic arterial pressure