Fig. 5

Changes in the serum metabolome and functional enrichment of serum metabolite features. A PLS-DA plot of serum metabolite profiles, which indicates the significant differentiation of serum metabolite profiles among the three weaning periods. B The differential serum metabolite features. KEGG pathway enrichment analysis based on the metabolite features altered among the three weaning periods (C-E). The X-axis and the size of the dots indicate the pathway impact of various altered metabolite features (the sum of the importance measures of the matched metabolites normalized to the sum of the importance measures of all metabolites in each pathway), and the Y-axis shows the P-value obtained for each pathway in the enrichment analysis. The size and color of the dots indicate the overall pathway impact