Fig. 5

Expression of the proteins with the highest differential abundance in bronchoalveolar lavage fluid (BALF) in West Highland white terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF). The top fifteen proteins with a resampled P value < 0.05 were ordered by magnitude of fold change and were groups according to direction of change. Top: nine proteins that were elevated in BALF in CIPF and bottom: six proteins that were decreased in CIPF WHWTs. Label-free abundances for individual samples are plotted, together with a box and whiskers plot (median, box: 50 percentile limits, whiskers, 25th and 75th percentiles). The proteins were: S100A12, CAMP, cathelicidin; CD177; TGFB1, transforming growth factor beta induced ig-h3; lumican; ARHGDIB, Rho GDP dissociation inhibitor beta; SUSD2, sushi domain containing 2; ITIH1, inter-alpha-trypsin inhibitor heavy chain 1, SERPING1, Serpin family G member 1; CES5A, carboxylic ester hydrolase; RETNLB, putatively resistin-like beta; CLCA1, chloride channel accessory 1; SULT1A1, sulfotransferase; CHI3L1, chitinase 3 like 1 and GSTP1, glutathione S-transferase P1