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Fig. 4 | BMC Veterinary Research

Fig. 4

From: Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis

Fig. 4

Quantitative comparison of the bronchoalveolar lavage fluid (BALF) proteomes in West Highland white terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF) and healthy WHWTs. Proteome differences between control and CIPF BALF were visualised using a volcano plot analysis of proteins identified with >1 unique peptide from trypsin analysis. The number of unique tryptic peptides identified is represented by the size of the symbol. Proteins above the grey line have a q-value < 0.05 (a). Samples were clustered and displayed in a heat map of the scaled abundance for the top 40 differentially expressed proteins (based on fold difference), dog clinical condition, arterial oxygen and the concentration of total bile acids in BALF (b). Details of the proteins are provided in Supplementary Figure 2. Data from arterial oxygen and total bile acids are from previous studies [2, 6]. The entire data set (265 proteins) was subjected to principal component analysis using all proteins identified with more than one unique peptide (c)

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