Table 1 Comparing xylazine, detomidine, medetomidine on physiological variables (mean ± standard deviation) during laparoscopic embryo (somatic cell nuclear transfer) transferring in 60 does. Animals were assigned to five intravenous groups: control (normal saline, 5 mL); XYL, xylazine (100 μg kg^− 1); DET, detomidine (50 μg kg^− 1); MED, medetomidine (20 μg kg^− 1); and DEX, dexmedetomidine (5 μg kg^− 1)

HR (beats minute^− 1)

Control

107 ± 5

106 ± 5

107 ± 3

118 ± 4 ^†

118 ± 3 ^†

119 ± 3 ^†

107 ± 4

108 ± 3

106 ± 4

XYL

105 ± 6

100 ± 6 ^*†

95 ± 5 ^*†

90 ± 6 ^*†

80 ± 6 ^*†

79 ± 4 ^*†

81 ± 4 ^*†

87 ± 4 ^*†

106 ± 5

DET

108 ± 3

100 ± 2 ^*†

97 ± 3 ^*†

94 ± 4 ^*†

84 ± 4 ^*†

82 ± 4 ^*†

84 ± 3 ^*†

89 ± 2 ^*†

107 ± 3

MED

103 ± 4

98 ± 3 ^*†

93 ± 5 ^*†

89 ± 4 ^*†

81 ± 3 ^*†

79 ± 4 ^*†

82 ± 3 ^*†

87 ± 3 ^*†

103 ± 3

DEX

107 ± 6

100 ± 4 ^*†

96 ± 6 ^*†

92 ± 5 ^*†

82 ± 5 ^*†

83 ± 5 ^*†

83 ± 4 ^*†

87 ± 4 ^*†

107 ± 6

RR

(breaths minute^− 1)

Control

29 ± 2

28 ± 2

28 ± 2

32 ± 1 ^†

32 ± 1 ^†

32 ± 1 ^†

28 ± 1

28 ± 1

29 ± 1

XYL

28 ± 1

27 ± 1

27 ± 1

26 ± 1 ^*†

24 ± 1 ^*†

23 ± 1 ^*†

25 ± 1 ^*†

27 ± 1

28 ± 1

DET

28 ± 2

27 ± 2

27 ± 2

26 ± 2 ^*†

24 ± 2 ^*†

23 ± 2 ^*†

25 ± 1 ^*†

27 ± 2

28 ± 2

MED

29 ± 2

28 ± 2

28 ± 2

27 ± 2 ^*†

25 ± 2 ^*†

24 ± 2 ^*†

25 ± 2 ^*†

27 ± 2

28 ± 2

DEX

29 ± 2

28 ± 2

28 ± 2

27 ± 2 ^*†

24 ± 2 ^*†

24 ± 2 ^*†

25 ± 2 ^*†

27 ± 2

28 ± 1

RT (° C)

Control

38.8 ± 0.2

38.8 ± 0.2

38.8 ± 0.3

38.9 ± 0.2

38.6 ± 0.3

38.6 ± 0.2

38.6 ± 0.2

38.7 ± 0.1

38.6 ± 0.1

XYL

38.7 ± 0.4

38.6 ± 0.1

38.7 ± 0.2

38.8 ± 0.2

38.8 ± 0.2

38.6 ± 0.2

38.7 ± 0.2

38.5 ± 0.2

38.8 ± 0.2

DET

38.6 ± 0.3

38.7 ± 0.2

38.6 ± 0.2

38.6 ± 0.2

38.8 ± 0.2

38.8 ± 0.3

38.8 ± 0.3

37.8 ± 0.3

38.6 ± 0.2

MED

38.8 ± 0.1

38.8 ± 0.1

38.7 ± 0.2

38.7 ± 0.2

38.6 ± 0.2

38.6 ± 0.2

37.9 ± 0.3

37.8 ± 0.3

38.7 ± 0.2

DEX

38.6 ± 0.2

38.7 ± 0.1

38.6 ± 0.2

38.7 ± 0.2

38.7 ± 0.1

38.7 ± 0.3

37.7 ± 0.3

38.7 ± 0.2

38.6 ± 0.3

Ruminal motility (contraction minutes^− 1)

Control

2

2

2

2

2

2

2

2

2

XYL

2

1 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

1 ^*†

1 ^*†

DET

2

1 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

1 ^*†

1 ^*†

MED

2

1 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

1 ^*†

1 ^*†

DEX

2

1 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

0 ^*†

1 ^*†

1 ^*†

Cortisol (nmol/l)

Control

59 ± 11

–

–

–

–

80 ± 8 ^†

–

–

61 ± 14

XYL

60 ± 13

–

–

–

–

34 ± 6 ^*†

–

–

48 ± 4 ^*†

DET

63 ± 12

–

–

–

–

34 ± 7 ^*†

–

–

45 ± 3 ^*†

MED

60 ± 13

–

–

–

–

36 ± 4 ^*†

–

–

46 ± 5 ^*†

DEX

63 ± 11

–

–

–

–

35 ± 5 ^*†

–

44 ± 3 ^*†