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Table 2 Hematological parameters at 5, 10, 15, 30, 60, 90, 120 and 150 min following intrathecal saline (SAL), xylazine (XYL) and xylazine- adenosine (XYL-AD) in XYL-sedated goats

From: Intrathecal adenosine enhances the antinociception of Xylazine in goats

Parameter

Group

Time after intrathecal administration (minutes)

Base b

5

10

15

30

60

90

120

150

WBC

(× 109/L)

SAL

13.3 ± 2

12.5 ± 1.8

12.1 ± 1.7

12.2 ± 1.9

12.3 ± 1.7

12.8 ± 1.7

12.3 ± 1.6

12 ± 1.6

12.3 ± 2.2

XYL

11.8 ± 1.4

11.5 ± 1.7

11.1 ± 1.4

10 ± 1.8

9.5 ± 1.6ab

ap < 0.001

bp = 0.046

10.1 ± 1.3ab

ap = 0.019

bp = 0.035

11 ± 1.5a

P = 0.019

11.5 ± 1.8

12 ± 1.4

XYL-AD

12.3 ± 2.8

12.1 ± 2.5

11.5 ± 2.5

9.5 ± 2.3a

p = 0.001

8.8 ± 2.4a

p < 0.001

9.1 ± 2.5ab

ap < 0.001

bp = 0.043

10.3 ± 2.8a

p < 0.001

11.1 ± 2.9a

p = 0.004

12 ± 2.6

Lymphocyte %

SAL

50.8 ± 4.1

50.3 ± 3.8

49.7 ± 3.9

49.5 ± 4.1

49.6 ± 3.8a

p = 0.004

49 ± 4.3a

p = 0.019

49 ± 4

49.8 ± 3.5

50.1 ± 3.6

XYL

50.8 ± 3.4

50.3 ± 3.3

49.8 ± 3.6

48.8 ± 3.6a

p = 0.003

47.8 ± 3.6a

p < 0.001

46.5 ± 2.5a

p = 0.001

47 ± 2.8a

p = 0.001

48.3 ± 2.4a

p = 0.030

49.1 ± 2.4

XYL-AD

50 ± 4.2

49.6 ± 4.5

49 ± 4.4

48.2 ± 4.5a

p = 0.014

46.9 ± 4.4a

p = 0.002

45.4 ± 4.4a

p = 0.004

46.3 ± 4.5a

p = 0.009

47.1 ± 4.4a

p = 0.009

48 ± 4.2

Granulocyte %

SAL

37.6 ± 4.2

37.5 ± 4

39.8 ± 4.8

41.8 ± 3.7

43.8 ± 3.8a

p = 0.015

44.1 ± 3.9a

p = 0.003

44.8 ± 2.4a

p = 0.007

41.6 ± 3.4

39 ± 3

XYL

37.8 ± 3.4

38.3 ± 3.6

40.6 ± 5.2

43.1 ± 4.1

47.5 ± 5.3a

p = 0.022

46.5 ± 4.3a

p = 0.011

48.5 ± 4.3a

p = 0.011

42.4 ± 5.3

41.6 ± 4.8

XYL-AD

35.1 ± 2.9

35.5 ± 2.8

36.6 ± 1.9

37.6 ± 2.9a

p = 0.012

38.9 ± 3.7a

p = 0.014

41.6 ± 2.6a

p = 0.030

40.1 ± 2.5b

p = 0.024

39.3 ± 2.4

38.5 ± 2.6

RBC

(× 1012/L)

SAL

20.1 ± 2.1

20 ± 2.3

19.6 ± 2.5

18.6 ± 2.1a

16.8 ± 1.8a

p = 0.019

17.1 ± 1.6a

p = 0.010

18 ± 1.6

18.1 ± 2

19.3 ± 1.9

XYL

20 ± 1.4

20 ± 0.8

19.6 ± 1.5

17.8 ± 1.1a

p = 0.004

16.3 ± 1.2a

p = 0.002

17.3 ± 1.2a

p = 0.014

17.6 ± 0.8a

p = 0.024

18.3 ± 0.5

19.5 ± 1

XYL-AD

19.3 ± 3

19 ± 2.6

18 ± 2.5

16.5 ± 2.4a

p = 0.001

15 ± 2.2a

p = 0.003

15.8 ± 2a

p = 0.011

16.8 ± 2.1a

p = 0.019

17.3 ± 2.5a

p = 0.013

18.5 ± 2.2

HCT (%)

SAL

29.5 ± 1.7

29.3 ± 2.3

28.1 ± 2.4

27.3 ± 2a

p = 0.004

27.1 ± 2.3a

p = 0.010

27 ± 2a

p = 0.014

27.8 ± 1.9a

p = 0.009

27.5 ± 1.7

28.6 ± 1.2

XYL

29.6 ± 2.7

29.5 ± 3

27.3 ± 2.6 a

p < 0.001

26 ± 2.2a

p < 0.001

25.6 ± 2.3a

p = 0.003

26 ± 1.8a

p = 0.006

26.8 ± 1.7a

p = 0.016

29 ± 2.3

29.5 ± 2.8

XYL-AD

28.3 ± 2.7

27.6 ± 2.8

26.6 ± 2.8a

p = 0.002

25.6 ± 2.8a

p < 0.001

24.6 ± 2.6a

p < 0.001

25.3 ± 3.1a

p = 0.016

26.3 ± 3.1

27 ± 2.2

28.1 ± 2.5

HGB (g/dL)

SAL

9 ± 0.6

8.7 ± 0.8

8.4 ± 0.9

8 ± 0.8a

p = 0.005

8.1 ± 0.9a

p = 0.014

7.8 ± 0.9a

p = 0.007

7.9 ± 0.8a

p = 0.011

8.2 ± 0.7a

p = 0.020

8.5 ± 0.8

XYL

9.2 ± 0.6

9 ± 0.8

8.7 ± 0.9

8.2 ± 0.8a

p = 0.007

7.8 ± 0.9a

p = 0.003

7.6 ± 0.7a

p = 0.003

7.8 ± 0.8a

p = 0.008

8.2 ± 0.9 a

p = 0.019

8.6 ± 1

XYL-AD

9.4 ± 0.5

9.3 ± 0.5

8.9 ± 0.9 a

p = 0.013

8.5 ± 0.8a

p = 0.003

8.3 ± 0.5a

p = 0.002

8.2 ± 0.6a

p = 0.001

8.6 ± 0.6a

p = 0.004

8.6 ± 0.7a

p = 0.006

8.9 ± 0.6a

p = 0.010

MCV (fL)

SAL

22.5 ± 1.3

22.1 ± 1.7

21.3 ± 1.5

20 ± 1a

p = 0.004

19.5 ± 1a

p = 0.032

20 ± 1.4

21.3 ± 1.5

21.5 ± 1.2

22 ± 1.2

XYL

22.3 ± 1.7

21.8 ± 2

21.6 ± 2.5

20.2 ± 1.5a

p = 0.004

19.8 ± 1.4a

p = 0.009

20.3 ± 1.6a

p = 0.016

21 ± 1.6

21.8 ± 1.7

22.1 ± 2

XYL-AD

21.5 ± 3

21 ± 2.8

20.7 ± 2.8

19.9 ± 3.3a

p < 0.001

19.1 ± 3.4a

p < 0.001

19.5 ± 3.4a

p = 0.001

20.4 ± 3.2a

p < 0.001

21 ± 3.1

21.2 ± 2.8

MCH (pg)

SAL

7.8 ± 0.9

8 ± 0.8

7.8 ± 0.7

8.8 ± 1

9.9 ± 1a

p = 0.023

10 ± 0.8a

p = 0.017

10.4 ± 1.1a

p = 0.025

9.4 ± 0.9

8.4 ± 1

XYL

7.5 ± 0.6

7.6 ± 0.8

8 ± 0.8

9.5 ± 1a

p = 0.001

10.3 ± 1a

p < 0.001

10.8 ± 1.2a

p < 0.001

10.6 ± 1.2a

p < 0.001

9.6 ± 1.2a

p = 0.003

8.6 ± 1.2a

p = 0.38

XYL-AD

7 ± 1.3

7.1 ± 1.4

7.4 ± 1.1

8.8 ± 1.2a

p = 0.002

9.3 ± 1a

p = 0.003

10 ± 1.1a

p < 0.001

9.3 ± 0.9a

p = 0.002

8.5 ± 1a

p = 0.010

7.5 ± 1

MCHC

(g/ dL)

SAL

45.8 ± 2.6

45.1 ± 3.1

45 ± 4

46.8 ± 2.8

48.1 ± 3.2

48.2 ± 2.8a

p = 0.004

48.8 ± 1.9a

p = 0.010

46.5 ± 2.1

46 ± 2.2

XYL

44.5 ± 3.9

44 ± 4.1

45.8 ± 4.3

48.6 ± 4.3a

p = 0.002

50.6 ± 4.3a

p < 0.001

52.8 ± 3.8a

p < 0.001

50.8 ± 4.4a

p = 0.010

47.6 ± 4.1

45.3 ± 3.6

XYL-AD

47.1 ± 3.7

46.6 ± 3.3

47.8 ± 4.4

50.8 ± 3.7a

p < 0.001

52.5 ± 3.9a

p < 0.001

54.3 ± 3.3ab

ap < 0.001

bp = 0.018

52.5 ± 3.5a

p = 0.007

50.6 ± 3.6a

p = 0.002

48.1 ± 3.7

  1. WBC white blood count; RBC red blood count; HCT hematocrit; HGB hemoglobin; MCV mean corpuscular volume; MCH mean corpuscular hemoglobin; MCHC mean corpuscular hemoglobin concentration
  2. Data is expressed as mean ± SD (n = 6)
  3. asignificantly different from the base value (P < 0.05) within each group; bvalues taken before intramuscular xylazine and intrathecal injection
  4. bsignificantly different from the SAL group at the same time point (P < 0.05)