From: Intrathecal adenosine enhances the antinociception of Xylazine in goats
Parameter | Group | Time after intrathecal administration (minutes) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Base b | 5 | 10 | 15 | 30 | 60 | 90 | 120 | 150 | ||
WBC (× 109/L) | SAL | 13.3 ± 2 | 12.5 ± 1.8 | 12.1 ± 1.7 | 12.2 ± 1.9 | 12.3 ± 1.7 | 12.8 ± 1.7 | 12.3 ± 1.6 | 12 ± 1.6 | 12.3 ± 2.2 |
XYL | 11.8 ± 1.4 | 11.5 ± 1.7 | 11.1 ± 1.4 | 10 ± 1.8 | 9.5 ± 1.6ab ap < 0.001 bp = 0.046 | 10.1 ± 1.3ab ap = 0.019 bp = 0.035 | 11 ± 1.5a P = 0.019 | 11.5 ± 1.8 | 12 ± 1.4 | |
XYL-AD | 12.3 ± 2.8 | 12.1 ± 2.5 | 11.5 ± 2.5 | 9.5 ± 2.3a p = 0.001 | 8.8 ± 2.4a p < 0.001 | 9.1 ± 2.5ab ap < 0.001 bp = 0.043 | 10.3 ± 2.8a p < 0.001 | 11.1 ± 2.9a p = 0.004 | 12 ± 2.6 | |
Lymphocyte % | SAL | 50.8 ± 4.1 | 50.3 ± 3.8 | 49.7 ± 3.9 | 49.5 ± 4.1 | 49.6 ± 3.8a p = 0.004 | 49 ± 4.3a p = 0.019 | 49 ± 4 | 49.8 ± 3.5 | 50.1 ± 3.6 |
XYL | 50.8 ± 3.4 | 50.3 ± 3.3 | 49.8 ± 3.6 | 48.8 ± 3.6a p = 0.003 | 47.8 ± 3.6a p < 0.001 | 46.5 ± 2.5a p = 0.001 | 47 ± 2.8a p = 0.001 | 48.3 ± 2.4a p = 0.030 | 49.1 ± 2.4 | |
XYL-AD | 50 ± 4.2 | 49.6 ± 4.5 | 49 ± 4.4 | 48.2 ± 4.5a p = 0.014 | 46.9 ± 4.4a p = 0.002 | 45.4 ± 4.4a p = 0.004 | 46.3 ± 4.5a p = 0.009 | 47.1 ± 4.4a p = 0.009 | 48 ± 4.2 | |
Granulocyte % | SAL | 37.6 ± 4.2 | 37.5 ± 4 | 39.8 ± 4.8 | 41.8 ± 3.7 | 43.8 ± 3.8a p = 0.015 | 44.1 ± 3.9a p = 0.003 | 44.8 ± 2.4a p = 0.007 | 41.6 ± 3.4 | 39 ± 3 |
XYL | 37.8 ± 3.4 | 38.3 ± 3.6 | 40.6 ± 5.2 | 43.1 ± 4.1 | 47.5 ± 5.3a p = 0.022 | 46.5 ± 4.3a p = 0.011 | 48.5 ± 4.3a p = 0.011 | 42.4 ± 5.3 | 41.6 ± 4.8 | |
XYL-AD | 35.1 ± 2.9 | 35.5 ± 2.8 | 36.6 ± 1.9 | 37.6 ± 2.9a p = 0.012 | 38.9 ± 3.7a p = 0.014 | 41.6 ± 2.6a p = 0.030 | 40.1 ± 2.5b p = 0.024 | 39.3 ± 2.4 | 38.5 ± 2.6 | |
RBC (× 1012/L) | SAL | 20.1 ± 2.1 | 20 ± 2.3 | 19.6 ± 2.5 | 18.6 ± 2.1a | 16.8 ± 1.8a p = 0.019 | 17.1 ± 1.6a p = 0.010 | 18 ± 1.6 | 18.1 ± 2 | 19.3 ± 1.9 |
XYL | 20 ± 1.4 | 20 ± 0.8 | 19.6 ± 1.5 | 17.8 ± 1.1a p = 0.004 | 16.3 ± 1.2a p = 0.002 | 17.3 ± 1.2a p = 0.014 | 17.6 ± 0.8a p = 0.024 | 18.3 ± 0.5 | 19.5 ± 1 | |
XYL-AD | 19.3 ± 3 | 19 ± 2.6 | 18 ± 2.5 | 16.5 ± 2.4a p = 0.001 | 15 ± 2.2a p = 0.003 | 15.8 ± 2a p = 0.011 | 16.8 ± 2.1a p = 0.019 | 17.3 ± 2.5a p = 0.013 | 18.5 ± 2.2 | |
HCT (%) | SAL | 29.5 ± 1.7 | 29.3 ± 2.3 | 28.1 ± 2.4 | 27.3 ± 2a p = 0.004 | 27.1 ± 2.3a p = 0.010 | 27 ± 2a p = 0.014 | 27.8 ± 1.9a p = 0.009 | 27.5 ± 1.7 | 28.6 ± 1.2 |
XYL | 29.6 ± 2.7 | 29.5 ± 3 | 27.3 ± 2.6 a p < 0.001 | 26 ± 2.2a p < 0.001 | 25.6 ± 2.3a p = 0.003 | 26 ± 1.8a p = 0.006 | 26.8 ± 1.7a p = 0.016 | 29 ± 2.3 | 29.5 ± 2.8 | |
XYL-AD | 28.3 ± 2.7 | 27.6 ± 2.8 | 26.6 ± 2.8a p = 0.002 | 25.6 ± 2.8a p < 0.001 | 24.6 ± 2.6a p < 0.001 | 25.3 ± 3.1a p = 0.016 | 26.3 ± 3.1 | 27 ± 2.2 | 28.1 ± 2.5 | |
HGB (g/dL) | SAL | 9 ± 0.6 | 8.7 ± 0.8 | 8.4 ± 0.9 | 8 ± 0.8a p = 0.005 | 8.1 ± 0.9a p = 0.014 | 7.8 ± 0.9a p = 0.007 | 7.9 ± 0.8a p = 0.011 | 8.2 ± 0.7a p = 0.020 | 8.5 ± 0.8 |
XYL | 9.2 ± 0.6 | 9 ± 0.8 | 8.7 ± 0.9 | 8.2 ± 0.8a p = 0.007 | 7.8 ± 0.9a p = 0.003 | 7.6 ± 0.7a p = 0.003 | 7.8 ± 0.8a p = 0.008 | 8.2 ± 0.9 a p = 0.019 | 8.6 ± 1 | |
XYL-AD | 9.4 ± 0.5 | 9.3 ± 0.5 | 8.9 ± 0.9 a p = 0.013 | 8.5 ± 0.8a p = 0.003 | 8.3 ± 0.5a p = 0.002 | 8.2 ± 0.6a p = 0.001 | 8.6 ± 0.6a p = 0.004 | 8.6 ± 0.7a p = 0.006 | 8.9 ± 0.6a p = 0.010 | |
MCV (fL) | SAL | 22.5 ± 1.3 | 22.1 ± 1.7 | 21.3 ± 1.5 | 20 ± 1a p = 0.004 | 19.5 ± 1a p = 0.032 | 20 ± 1.4 | 21.3 ± 1.5 | 21.5 ± 1.2 | 22 ± 1.2 |
XYL | 22.3 ± 1.7 | 21.8 ± 2 | 21.6 ± 2.5 | 20.2 ± 1.5a p = 0.004 | 19.8 ± 1.4a p = 0.009 | 20.3 ± 1.6a p = 0.016 | 21 ± 1.6 | 21.8 ± 1.7 | 22.1 ± 2 | |
XYL-AD | 21.5 ± 3 | 21 ± 2.8 | 20.7 ± 2.8 | 19.9 ± 3.3a p < 0.001 | 19.1 ± 3.4a p < 0.001 | 19.5 ± 3.4a p = 0.001 | 20.4 ± 3.2a p < 0.001 | 21 ± 3.1 | 21.2 ± 2.8 | |
MCH (pg) | SAL | 7.8 ± 0.9 | 8 ± 0.8 | 7.8 ± 0.7 | 8.8 ± 1 | 9.9 ± 1a p = 0.023 | 10 ± 0.8a p = 0.017 | 10.4 ± 1.1a p = 0.025 | 9.4 ± 0.9 | 8.4 ± 1 |
XYL | 7.5 ± 0.6 | 7.6 ± 0.8 | 8 ± 0.8 | 9.5 ± 1a p = 0.001 | 10.3 ± 1a p < 0.001 | 10.8 ± 1.2a p < 0.001 | 10.6 ± 1.2a p < 0.001 | 9.6 ± 1.2a p = 0.003 | 8.6 ± 1.2a p = 0.38 | |
XYL-AD | 7 ± 1.3 | 7.1 ± 1.4 | 7.4 ± 1.1 | 8.8 ± 1.2a p = 0.002 | 9.3 ± 1a p = 0.003 | 10 ± 1.1a p < 0.001 | 9.3 ± 0.9a p = 0.002 | 8.5 ± 1a p = 0.010 | 7.5 ± 1 | |
MCHC (g/ dL) | SAL | 45.8 ± 2.6 | 45.1 ± 3.1 | 45 ± 4 | 46.8 ± 2.8 | 48.1 ± 3.2 | 48.2 ± 2.8a p = 0.004 | 48.8 ± 1.9a p = 0.010 | 46.5 ± 2.1 | 46 ± 2.2 |
XYL | 44.5 ± 3.9 | 44 ± 4.1 | 45.8 ± 4.3 | 48.6 ± 4.3a p = 0.002 | 50.6 ± 4.3a p < 0.001 | 52.8 ± 3.8a p < 0.001 | 50.8 ± 4.4a p = 0.010 | 47.6 ± 4.1 | 45.3 ± 3.6 | |
XYL-AD | 47.1 ± 3.7 | 46.6 ± 3.3 | 47.8 ± 4.4 | 50.8 ± 3.7a p < 0.001 | 52.5 ± 3.9a p < 0.001 | 54.3 ± 3.3ab ap < 0.001 bp = 0.018 | 52.5 ± 3.5a p = 0.007 | 50.6 ± 3.6a p = 0.002 | 48.1 ± 3.7 |