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Table 4 Median (interquartile range) blood glucose and hormone and concentrations measured over 42 days in 37 horses during a rapid (n = 27) or slow (n = 10) improvement following hyperinsulinaemia-associated laminitis. All samples were collected following an overnight fast, except on d 0

From: Demographic, morphologic, hormonal and metabolic factors associated with the rate of improvement from equine hyperinsulinaemia-associated laminitis

Analyte

Improvement rate

Days after diagnosis

  

0

4

14

25

42

Glucose, mM

Fast

6 (5.20–7.0)

5.2 (4.9–5.6)*

5.2 (4.6–5.7)*

5.2 (4.9–5.6)*

5.2 (4.7–5.7)

Slow

6.7 (5.26–7.73)

5.75 (5.33–6.75)

6.05 (4.88–6.68)

5.95 (5.28–6.98)

5.9 (5–6.75)

Insulin, μIU/mL

Fast

36 (12–130)

10 (5–19.0)

10 (5–16)*

9 (5–20)*

13 (5–19)†

Slow

25 (13.25–110)

16 (8.75–86.3)

15.5 (11–45.3)

23.5 (9.75–50.8)

20 (12–38)

ACTH, pg/mL

Fast

31 (17.4–52.6)

24.1 (12.8–38.8)

22.6 (14.1–48.2)

28.5 (14.9–64.7)

37.9 (17.4–117)

Slow

18.0 (14.2–39.6)

17.5 (14.1–37.1)

15.7 (13.4–29.3)

17.9 (15.8–35.0)

22.6 (16.9–58.7)

Leptin, ng/mL

Fast

21.0 (16.5–25.8)

15.9 (11.9–28.6)

15.6 (12.4–28.1)

18.8 (9.3–27.7)

17.4 (12–26.7)

Slow

18.4 (15.6–42.8)

20.1 (14.2–34.2)

19 (14.6–37.4)

17.3 (14.4–43.2)

16.6 (13.6–47.2)

  1. P < 0.1, *P < 0.05, comparisons are between fast and slow groups on the same day, Mann-Whitney Rank Sum Test