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Table 5 ICRS histological grading scale scores

From: Osteochondral regeneration of the femoral medial condyle by using a scaffold-free 3D construct of synovial membrane-derived mesenchymal stem cells in horses

Feature

Score

Horse No. 1

Horse No. 2

Horse No. 3

Mean ± SE

R

L

R

L

R

L

R

L

Surface

Smooth/continuous

3

3

3

3

0

0

0

2.0 ± 1.0

1.0 ± 1.0

Discontinuities/irregulatrity

0

Matrix

Hyaline

3

2

1

1

0

0

0

1.0 ± 0.6

0.3 ± 0.3

Mixture; hyaline/fibrocartilage

2

Fibrocartilage

1

Fibrous tissue

0

Cell distribution

Columnar

3

1

1

0

0

0

0

0.3 ± 0.3

0.3 ± 0.3

Mixed/columnar clusters

2

Clusters

1

Individual cells/disorganized

0

Viability of

cell population

Predominantly viable

3

3

3

3

1

3

3

3.0 ± 0.0

2.3 ± 0.7

Partially viable

1

< 10% viable

0

Subchondral bone

Normal

3

2

2

2

1

1

1

1.7 ± 0.3

1.3 ± 0.3

Increased remodeling

2

Bone necrosis/granulation tissue

1

Detached/fracture/callus at base

0

Cartilage mineralization

(calcified cartilage)

Normal

3

0-

0

0

0

0

0

0.0 ± 0.0

0.0 ± 0.0

Abnormal/inappropriate location

0

Average (0–3)

1.8

1.7

1.5

0.33

0.7

0.7

1.3 ± 0.4

0.9 ± 0.4

  1. RF, Right forelimb; LF, left forelimb; ICRS, International Cartilage Repair Society