Persistent hypercobalaminemia three months after successful gradual attenuation of extrahepatic shunts in dogs: a prospective cohort study

Table 1 Concentrations of different vitamins and methylmalonic acid in dogs with extrahepatic portosystemic shunts

	Diagnosis	Surgery*	Three monthspostoperatively*	Reference interval
	median (range)	median (range)	median (range)
Vitamin A (μg/dL)	18.2	20.7	88.3‡°	30.6 – 169.6^[18]
Vitamin A (μg/dL)	(8.8 – 79.5)	(7.6 – 85.9)	(51.6 – 182.2)	30.6 – 169.6^[18]
25-hydroxyvitamin D (ng/mL)	51.8	60.1	89.6	20.0 – 115.0
25-hydroxyvitamin D (ng/mL)	(19.4 – 109.0)	(32.2 – 98.1)	(49.3 – >150.0)**	20.0 – 115.0
Folic Acid (μg/L)	8.1	10.5	14.8‡°	4.0 – 16.0
Folic Acid (μg/L)	(5.2 -14.5)	(5.6 – 15.6)	(11.5 – 17.7)	4.0 – 16.0
Cobalamin (ng/L)	736	885	715	99 – 658
Cobalamin (ng/L)	(470 – 1388)	(453 – 1290)	(394 – 999)	99 – 658
Methylmalonic acid (μg/L)	93.6	37.4†	60.6	45.4 – 129.0
Methylmalonic acid (μg/L)	(41.9 – 250.1)	(28.0 – 462.7)	(46.1 – 100.6)	45.4 – 129.0

^*Only data after the second surgery are reported of the dog with two single EHPSS that underwent two surgeries
^**The upper limit of detection of 25-hydroxyvitamin D in the chemiluminescent microparticle immunoassay was 150.0 ng/mL
^[18]published ranges of vitamin A concentrations in healthy dogs, also determined by reversed phase high performance liquid chromatography [18].
Statistically significant differences based on Kruskal-Wallis tests are indicated
†significant difference between median serum concentrations at diagnosis and time of surgery
‡significant difference between median serum concentrations at diagnosis and three months postoperatively
°significant difference between median serum concentrations at time of surgery and three months postoperatively

ISSN: 1746-6148