Table 4 Accuracy of complete blood count (CBC) model at various cut-off values i.e. at various combinations of CBC measurements included in the model. The optimal cut-off value determined on the basis of the highest Youden’s index (J) highlighted (the combination above it i.e. WBC < 18 G/L, BNC < 0.27 G/L, and EC > 0.3 G/L is the only to be considered as negative)
From: Application of a complete blood count to screening lethargic and anorectic cats for pancreatitis
Combinations of CBC measurements | Result of CBC model | Accuracy measures | ||||||
|---|---|---|---|---|---|---|---|---|
WBC ≥ 18 | BNC ≥ 0.27 | EC > 0.3 | Se (CI 95%) | Sp (CI 95%) | LR+ (CI 95%) | LR- (CI 95%) | J | |
No | No | Yes | 0.275 | – | – | – | – | – |
No | No | No | 0.628 | 91.8 (80.8, 96.8) | 58.3 (38.8, 75.5) | 2.2 (1.4, 3.6) | 0.14 (0.05, 0.38) | 50.2 (39.4, 61.0) |
No | Yes | Yes | 0.649 | 67.3 (53.4, 78.8) | 79.2 (59.5, 90.8) | 3.2 (1.4, 7.2) | 0.41 (0.26, 0.65) | 46.5 (35.9, 57.2) |
Yes | No | Yes | 0.835 | 57.1 (43.3, 70.0) | 83.3 (64.1, 93.3) | 3.4 (1.4, 8.7) | 0.51 (0.36, 0.74) | 40.5 (30.1, 50.9) |
No | Yes | No | 0.892 | 53.1 (39.4, 66.3) | 87.5 (69.0, 95.7) | 4.2 (1.4, 12.6) | 0.54 (0.38, 0.75) | 40.6 (30.7, 50.4) |
Yes | No | No | 0.957 | 30.6 (19.5, 44.5) | 100 (86.2, 100) | +∞ | 0.69 (0.58, 0.84) | 30.6 (24.0, 37.2) |
Yes | Yes | Yes | 0.961 | 24.5 (14.6, 38.1) | 100 (86.2, 100) | +∞ | 0.76 (0.64, 0.89) | 24.5 (18.3, 30.6) |
Yes | Yes | No | 0.991 | 6.1 (2.1, 16.5) | 100 (86.2, 100) | +∞ | 0.94 (0.87, 1.01) | 6.1 (2.7, 9.5) |