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Fig. 5 | BMC Veterinary Research

Fig. 5

From: Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy

Fig. 5

Protein-protein interaction (PPI) network and analysis of the hub genes of differentially expressed genes (DEGs). A PPI analysis of using STRING networks reveals the tight interaction between the DEGs. A thicker edge indicates a higher confidence score of the interaction; B Clustering analysis of the PPI network revealed the most important module, identified using Cytoscape (MCODE plugin); C The hub genes were identified by the cytoHubba tool in Cytoscape. The selected nodes are shown with a color scheme from essential (red) to crucial (yellow)

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