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Fig. 2 | BMC Veterinary Research

Fig. 2

From: Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy

Fig. 2

Cytology, histopathology, mitosis, and tumour growth curves of various tumours. A The three tumours shared similarities in cytological features, such as the moderate to low nuclei-cytoplasmic ratio, cytoplasmic vacuolization, and huge nucleoli in week 10; however, the intracytoplasmic vacuolization and size of the cells indicated greater malignancy of XCTVTs (top middle) and MCTVTs (top right) than of CTVTs (top left). Histologically, these three tumours were composed of round, oval or polyhedral cells with a moderate to small nuclei-cytoplasmic ratio. MCTVTs (bottom right) had a more progressive morphology, such as anisokaryosis and distinct borders of tumour cells than CTVTs (bottom left) and XCTVTs (bottom middle); B Mitotic counts of MCTVTs (32 ± 2.65) and XCTVTs (50 ± 7.81) were significantly higher than those of CTVTs (19.33 ± 1.53) (n = 3 in each group); C Tumour growth curves showed that MCTVTs were more aggressive than CTVTs in dogs. All data are presented as mean ± SD and statistical significance was calculated by unpaired t test (**, p < 0.01)

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BMC Veterinary Research

ISSN: 1746-6148

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