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Fig. 1 | BMC Veterinary Research

Fig. 1

From: Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy

Fig. 1

Schema of tumour model establishment. A To establish this canine animal model, primarily spontaneous canine transmissible venereal tumours (CTVTs) on the external genitalia of one male dog were used for the original transplantation. Dogs were inoculated subcutaneously with freshly prepared CTVT cells on their back; B CTVTs harvested from the tumour-bearing dogs were inoculated into immunodeficient NOD/SCID mice. Without immune cells attacking, the tumours grew in NOD/SCID mice and were called xenograft canine transmissible venereal tumours (XCTVTs); C Next, XCTVT cells were inoculated subcutaneously into beagles, and the tumours which grew on the beagles were defined as mouse canine transmissible venereal tumours (MCTVTs)

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