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Fig. 8 | BMC Veterinary Research

Fig. 8

From: Investigation of the effects of mTOR inhibitors rapamycin and everolimus in combination with carboplatin on canine malignant melanoma cells

Fig. 8

Graph representation of real-time metabolic evaluation of mTOR inhibitor treatment. Analysis performed following 24-h incubation with rapamycin (10 nM) or everolimus (10 nM). Glycolytic stress test measuring ECAR after real-time injection of glucose (10 mM), oligomycin (1 μM), and 2-deoxy-D-glucose (2-DG) (100 mM) at times indicated. X-axis and Y-axis represent time and ECAR respectively. The error bars represent mean +/− SD with a technical replicate of N = 10. Empty round symbols represent vehicle control. Filled squared symbols represent mTOR inhibitors. DG, Deoxy-D-glucose; ECAR, extracellular acidification rate

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BMC Veterinary Research

ISSN: 1746-6148

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