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Fig. 2 | BMC Veterinary Research

Fig. 2

From: Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®)

Fig. 2

Clinical and histopathology images from Dog 7. Significant bilateral periocular and facial alopecia following treatment with difluprednate OU BID for 16 months (a,b). Unilateral regrowth of hair on right side of face approximately 5 months following discontinuation of difluprednate OD (c,d). Alopecia of the left palmar metacarpus while receiving difluprednate OS BID (e). Photomicrograph from a skin biopsy of the right cheek while receiving difluprednate OU BID (H&E) (f). There is severe follicular atrophy, mild/moderate follicular keratosis, multifocal intrafollicular mites consistent with Demodex and mild/moderate orthokeratosis. Scale bar = 200 μm

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