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Fig. 2 | BMC Veterinary Research

Fig. 2

From: Identification of new candidate biomarkers to support doxorubicin treatments in canine cancer patients

Fig. 2

A Generation of 15N-labeled bacterial DNA and concept of mass pairing to facilitate adduct detection. Values correspond to mass differences (14N- in blue and 15N- in green) for each DNA base depending on the number of nitrogens present. B Extracted ion chromatograms (EIC, 5 ppm) of the exact masses that triggered an MS3 fragmentation event from the reaction of DOX with CT-DNA (top), 14N-bacterial DNA (center), or 15N-bacterial DNA (bottom) in the presence of formaldehyde. Only those masses that triggered an MS3 in DOX-treated samples, but not in the negative controls are reported

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