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Table 4 Analysis of whole blood-thromboelastography (WB-TEG) and routine plasma based coagulation tests between clinically healthy, mild gastrointestinal (GI) and severe GI disease horse groups. Median and range for WB-TEG and routine coagulation parameters fibrinogen, activated partial thromboplastin time (aPTT), prothrombin time (PT), anti-thrombin (AT) and d-dimer in healthy horses (healthy control), and horses with mild or severe GI diseases. P-value column: one-way ANOVA or a Kruskal-Wallis test depending on normality of data across all three groups with a significant level of < 0.05. a Post hoc statistical difference between healthy and severe GI disease, b Post hoc statistical difference between mild and severe GI disease. SP: split point, R: reaction time, K: clot formation time, α: alpha angle, MA: maximum amplitude, G: shear elastic force, LY30: lysis 30 min, LY60: lysis 60 min (min.)

From: A pilot study evaluating the Calibrated Automated Thrombogram assay and application of plasma-thromboelastography for detection of hemostatic aberrations in horses with gastrointestinal disease

  

Clinically healthy

Mild GI disease

Severe GI disease

P-value

WB-TEG

SP (min.)

12.7 (8.2–17.1)

9.8 (4.4–22.6)

10.8 (5.8–15.9)

0.23

R (min.)

16.6 (10.5–20.6)

11.6 (5.2–29.5)

13.5 (7.2–19.1)

0.29

α (degrees)

26.35 (17.2–41.7)

39.3 (13.3–65.4)

35.6 (18.5–54.5)

0.26

K (min.)

7.15 (4.2–13)

4.9 (2–18.4)

5.4 (3.4–11.8)

0.13

MA (mm)

51.55 (35–60.1)

56.4 (49.5–73.6)

52.2 (40.9–77.6)

0.18

G (dynes/cm2)

5.3 (2.7–7.5)

7 (4.9–13.9)

5.5 (3.5–17.4)

0.15

Ly30 (%)

0 (0–1.5)

0.1 (0–0.6)

0 (0–0.9)

0.9

Ly60 (%)

2.35 (0.2–6.1)

2.9 (0–4.4)

1.3 (0.1–4.4)

0.32

Conventional haemostatic markers

Fibrinogen (g/L)

3.17 (2.87–3.53)

3.72 (2.17–5.67)

3.17 (2.57–7.01)

0.14

aPTT (sec)

47.15 (44.30–57.90)

48.80 (39.30–51.4)

48.00 (40.60–56.30)

0.62

PT (sec)

13.85 (13.10–14.00)

13.60 (12.70–14.10)

14.10 (12.50–17.30)

0.15

AT (%)

210.5 (189.00–239.00)

223.00 (195.00–246.00)

197.00 (158.00–260.00)

0.14

D-dimer

0.08 (0.05–0.1)

0.09 (0.05–0.18)

0.25 (0.1–6.41)

< 0.0001

< 0.0001a 0.0084b