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Table 4 Analysis of whole blood-thromboelastography (WB-TEG) and routine plasma based coagulation tests between clinically healthy, mild gastrointestinal (GI) and severe GI disease horse groups. Median and range for WB-TEG and routine coagulation parameters fibrinogen, activated partial thromboplastin time (aPTT), prothrombin time (PT), anti-thrombin (AT) and d-dimer in healthy horses (healthy control), and horses with mild or severe GI diseases. P-value column: one-way ANOVA or a Kruskal-Wallis test depending on normality of data across all three groups with a significant level of < 0.05. a Post hoc statistical difference between healthy and severe GI disease, b Post hoc statistical difference between mild and severe GI disease. SP: split point, R: reaction time, K: clot formation time, α: alpha angle, MA: maximum amplitude, G: shear elastic force, LY30: lysis 30 min, LY60: lysis 60 min (min.)

From: A pilot study evaluating the Calibrated Automated Thrombogram assay and application of plasma-thromboelastography for detection of hemostatic aberrations in horses with gastrointestinal disease

   Clinically healthy Mild GI disease Severe GI disease P-value
WB-TEG SP (min.) 12.7 (8.2–17.1) 9.8 (4.4–22.6) 10.8 (5.8–15.9) 0.23
R (min.) 16.6 (10.5–20.6) 11.6 (5.2–29.5) 13.5 (7.2–19.1) 0.29
α (degrees) 26.35 (17.2–41.7) 39.3 (13.3–65.4) 35.6 (18.5–54.5) 0.26
K (min.) 7.15 (4.2–13) 4.9 (2–18.4) 5.4 (3.4–11.8) 0.13
MA (mm) 51.55 (35–60.1) 56.4 (49.5–73.6) 52.2 (40.9–77.6) 0.18
G (dynes/cm2) 5.3 (2.7–7.5) 7 (4.9–13.9) 5.5 (3.5–17.4) 0.15
Ly30 (%) 0 (0–1.5) 0.1 (0–0.6) 0 (0–0.9) 0.9
Ly60 (%) 2.35 (0.2–6.1) 2.9 (0–4.4) 1.3 (0.1–4.4) 0.32
Conventional haemostatic markers Fibrinogen (g/L) 3.17 (2.87–3.53) 3.72 (2.17–5.67) 3.17 (2.57–7.01) 0.14
aPTT (sec) 47.15 (44.30–57.90) 48.80 (39.30–51.4) 48.00 (40.60–56.30) 0.62
PT (sec) 13.85 (13.10–14.00) 13.60 (12.70–14.10) 14.10 (12.50–17.30) 0.15
AT (%) 210.5 (189.00–239.00) 223.00 (195.00–246.00) 197.00 (158.00–260.00) 0.14
D-dimer 0.08 (0.05–0.1) 0.09 (0.05–0.18) 0.25 (0.1–6.41) < 0.0001
< 0.0001a 0.0084b