Table 3 Analysis of the calibrated automated thrombogram (CAT) and plasma-thromboelastography (plasma-TEG) between clinically healthy, mild gastrointestinal (GI) and severe GI disease horse groups. Median and range for plasma-TEG and thrombin generation parameters lag-time, time to peak (ttPeak), peak and endogenous thrombin potential (ETP). P-value column: one-way ANOVA or a Kruskal-Wallis test depending on normality of data across all three groups with a significance level of < 0.05. a Post hoc statistical significant difference between healthy and severe GI disease, b Post hoc statistical significant difference between mild and severe GI disease. SP: split point, R: reaction time, K: clot formation time, α: alpha angle, MA: maximum amplitude, G: shear elastic force, LY30: lysis 30 min, LY60: lysis 60 min (min.)
| Â | Â | Clinically healthy | Mild GI disease | Severe GI disease | P-value |
|---|---|---|---|---|---|
Plasma-TEG | SP (min.) | 11.55 (8.6–16) | 11.5 (7.8–16.8) | 9.2 (4.2–20.1) | 0.53 |
R (min.) | 13.6 (10.9–20.4) | 14.6 (9.3–21.3) | 11.3 (4.8–24.5) | 0.38 | |
α (degrees) | 18.1 (8.4–25.4) | 17.1 (9.5–32.6) | 27 (10.2–68.5) | 0.016 0.032a | |
K (min.) | 11.85 (9.5–17.9) | 10.85 (7.9–19.2) | 8.45 (1.4–16.9) | 0.14 | |
MA (mm) | 18.45 (11.7–25.2) | 22.3 (17–26) | 22.1 (13.4–34.4) | 0.023 0.017a | |
G (dynes/cm2) | 1.1 (0.7–1.7) | 1.4 (1–1.8) | 1.4 (0.8–2.6) | 0.022 0.017a | |
Ly30 (%) | 0 (0–0) | 0 (0–0) | 0 (0–2.3) | 0.53 | |
Ly 60 (%) | 0 (0–0) | 0 (0–0) | 0 (0–1.1) | 0.53 | |
CAT | Lag-time (min.) | 4.05 (3.4–5.33) | 3.72 (2.17–5.67) | 3.31 (2.7–7.22) | 0.20 |
Peak (nM) | 32.69 (19.49–47.57) | 29.2 (19.63–45.49) | 51.46 (15.35–112.4) | 0.040 0.04b | |
ttPeak (min.) | 11.87 (10.08–13) | 10.28 (8.75–13.89) | 9.33 (6.5–13.01) | 0.01 0.008a | |
ETP (nM/min.) | 333.1 (270.3–422.1) | 292 (179.7–350.8) | 346.8 (166.8–468.1) | 0.11 |