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Table 3 Analysis of the calibrated automated thrombogram (CAT) and plasma-thromboelastography (plasma-TEG) between clinically healthy, mild gastrointestinal (GI) and severe GI disease horse groups. Median and range for plasma-TEG and thrombin generation parameters lag-time, time to peak (ttPeak), peak and endogenous thrombin potential (ETP). P-value column: one-way ANOVA or a Kruskal-Wallis test depending on normality of data across all three groups with a significance level of < 0.05. a Post hoc statistical significant difference between healthy and severe GI disease, b Post hoc statistical significant difference between mild and severe GI disease. SP: split point, R: reaction time, K: clot formation time, α: alpha angle, MA: maximum amplitude, G: shear elastic force, LY30: lysis 30 min, LY60: lysis 60 min (min.)

From: A pilot study evaluating the Calibrated Automated Thrombogram assay and application of plasma-thromboelastography for detection of hemostatic aberrations in horses with gastrointestinal disease

   Clinically healthy Mild GI disease Severe GI disease P-value
Plasma-TEG SP (min.) 11.55 (8.6–16) 11.5 (7.8–16.8) 9.2 (4.2–20.1) 0.53
R (min.) 13.6 (10.9–20.4) 14.6 (9.3–21.3) 11.3 (4.8–24.5) 0.38
α (degrees) 18.1 (8.4–25.4) 17.1 (9.5–32.6) 27 (10.2–68.5) 0.016
0.032a
K (min.) 11.85 (9.5–17.9) 10.85 (7.9–19.2) 8.45 (1.4–16.9) 0.14
MA (mm) 18.45 (11.7–25.2) 22.3 (17–26) 22.1 (13.4–34.4) 0.023
0.017a
G (dynes/cm2) 1.1 (0.7–1.7) 1.4 (1–1.8) 1.4 (0.8–2.6) 0.022
0.017a
Ly30 (%) 0 (0–0) 0 (0–0) 0 (0–2.3) 0.53
Ly 60 (%) 0 (0–0) 0 (0–0) 0 (0–1.1) 0.53
CAT Lag-time (min.) 4.05 (3.4–5.33) 3.72 (2.17–5.67) 3.31 (2.7–7.22) 0.20
Peak (nM) 32.69 (19.49–47.57) 29.2 (19.63–45.49) 51.46 (15.35–112.4) 0.040
0.04b
ttPeak (min.) 11.87 (10.08–13) 10.28 (8.75–13.89) 9.33 (6.5–13.01) 0.01
0.008a
ETP (nM/min.) 333.1 (270.3–422.1) 292 (179.7–350.8) 346.8 (166.8–468.1) 0.11