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Table 2 Distribution of genes associated with antimicrobial resistance of 159 Streptococcus uberis isolated from clinical mastitis according to clinical outcomes recorded during the follow-up period

From: Whole-genome sequencing reveals high genetic diversity of Streptococcus uberis isolated from cows with mastitis

Resistance factor Product Antibiotic class Mortality (% of cows infected by positive strains) Bacteriological cure Clinical cure Loss of mammary quarter function. Reoccurrence of CM Total of positive strains
Dead Alive No Yes No Yes No Yes No Yes
n % n % n % n % n % n % n % n % n % n %
rlmA(II) 23 S rRNA (guanine(748)-N(1))-methyltransferase Macrolides, Lincosamides 31 19 28 81 88 55 71 45 20 13 139 87 142 89 17 11 121 76 38 24 159
rpoB DNA-directed RNA polymerase beta subunit Rifamycins, Peptide antibiotics 31 19 128 81 88 55 71 45 20 13 139 87 142 89 17 11 121 76 38 24 159
rpoC DNA-directed RNA polymerase beta’ subunit Myxopyronins Corallopyronins, Peptide antibiotics 31 19 128 81 88 55 71 45 20 13 139 87 142 89 17 11 121 76 38 24 159
S10p SSU ribosomal protein S10p Tetracyclines, Glycylcyclines 30 19 128 81 87 55 71 45 20 13 138 87 141 89 17 11 120 76 38 24 158
alr Alanine racemase Cycloserine 31 20 126 80 86 55 71 45 20 13 137 87 140 89 17 11 119 76 38 24 157
EF-G Translation elongation factor G Fusidic acid 31 20 126 80 87 55 70 45 20 13 137 87 140 89 17 11 119 76 38 24 157
S12p SSU ribosomal protein S12p Aminoglycosides 31 20 126 80 87 55 70 45 20 13 137 87 140 89 17 11 119 76 38 24 157
pgsA CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase Peptide antibiotics (daptomycin) 28 18 127 82 85 55 70 45 20 13 135 87 138 89 17 11 121 78 34 22 155
fabK Enoyl-[acyl-carrier-protein] reductase [FMN, NADH] Triclosan 30 19 124 81 84 55 70 45 20 13 134 87 138 90 16 10 116 75 38 25 154
kasA 3-oxoacyl-[acyl-carrier-protein] synthase, KASII Isoniazid, Triclosan 30 19 124 81 84 55 70 45 20 13 134 87 138 90 16 10 116 75 38 25 154
D Lincosamide nucleotidyltransferase = > Lnu(D) Lincosamides 30 20 122 80 83 55 69 45 20 13 132 87 135 89 17 11 114 75 38 25 152
liaF Membrane protein LiaF(VraT), specific inhibitor of LiaRS(VraRS) signaling pathway Peptide antibiotics (daptomycin) 30 20 121 80 84 56 67 44 20 13 131 87 134 89 17 11 113 75 38 25 151
LiaR Cell envelope stress response system LiaFSR, response regulator LiaR(VraR) Peptide antibiotics (daptomycin) 30 20 121 80 84 56 67 44 20 13 131 87 134 89 17 11 113 75 38 25 151
LiaS Cell envelope stress response system LiaFSR, sensor histidine kinase LiaS(VraS) Peptide antibiotics (daptomycin) 30 20 121 80 84 56 67 44 20 13 131 87 134 89 17 11 113 75 38 25 151
murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase Fosfomycin 30 20 121 80 84 56 67 44 20 13 131 87 134 89 17 11 113 75 38 25 151
gidB 16 S rRNA (guanine(527)-N(7))-methyltransferase Aminoglycosides 29 19 121 81 83 55 67 45 20 13 130 87 133 89 17 11 112 75 38 25 150
GdpD Glycerophosphoryl diester phosphodiesterase Peptide antibiotics (daptomycin) 30 20 119 80 83 56 66 44 20 13 129 87 132 89 17 11 111 74 38 26 149
folP Dihydropteroate synthase Sulfonamides 30 20 117 80 84 57 63 43 20 14 127 86 131 89 16 11 109 74 38 26 147
ddl D-alanine–D-alanine ligase Cycloserine 29 20 117 80 81 55 65 45 20 14 126 86 129 88 17 12 108 74 38 26 146
Iso-tRNA Isoleucyl-tRNA synthetase Mupirocin 30 21 116 79 83 57 63 43 20 14 126 86 130 89 16 11 109 75 37 25 146
folA, Dfr Dihydrofolate reductase Diaminopyrimidines 29 20 115 80 81 56 63 44 20 14 124 86 128 89 16 11 107 74 37 26 144
gyrB DNA gyrase subunit B Novobiocin 29 20 115 80 80 56 64 44 20 14 124 86 127 88 17 12 106 74 38 26 144
gyrA DNA gyrase subunit A Ciprofloxacin 30 21 113 79 80 56 63 44 20 14 123 86 127 89 16 11 106 74 37 26 143
EF-Tu Translation elongation factor Tu Elfamycins 29 21 112 79 77 55 64 45 20 14 121 86 127 90 14 10 105 74 36 26 141
tetM Tetracycline resistance, ribosomal protection type = > Tet(M) Tetracyclines 6 13 42 88 20 42 28 58 6 13 42 88 43 90 5 10 39 81 9 19 48
parC DNA topoisomerase IV subunit A Ciprofloxacin 0 00 7 100 4 57 3 43 2 29 5 71 6 86 1 14 7 100 0 00 7
ant (6)-I Aminoglycoside 6-nucleotidyltransferase Aminoglycosides 1 25 3 75 1 25 3 75 0 00 4 100 4 100 0 00 4 100 0 00 4
bceR Two-component response regulator BceR Peptide antibiotics (bacitracin) 1 50 1 50 1 50 1 50 0 00 2 100 2 100 0 00 1 50 1 50 2
lsa(E) ABC-F type ribosomal protection protein Lincosamides 0 00 1 100 0 00 1 100 0 00 1 100 1 100 0 00 1 100 0 00 1
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BMC Veterinary Research

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