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Table 1 Distribution of virulence factors genes of 159 Streptococcus uberis isolated from clinical mastitis according to clinical outcomes recorded during the follow-up period

From: Whole-genome sequencing reveals high genetic diversity of Streptococcus uberis isolated from cows with mastitis

Virulence factor Product Mortality (% of cows infected by positive strains) Bacteriological cure Clinical cure Loss of mammary quarter function. Reoccurrence of CM Total strains
Dead Alive No Yes No Yes No Yes No Yes
n % n % n % n % n % n % n % n % n % n %  
hasC UTP–glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) 31 19 128 81 88 55 71 45 20 13 139 87 142 89 17 11 121 76 38 24 159
leuS Leucyl-tRNA synthetase (EC 6.1.1.4) 31 19 128 81 88 55 71 45 20 13 139 87 142 89 17 11 121 76 38 24 159
perR Peroxide stress regulator PerR, FUR family 31 19 128 81 88 55 71 45 0 00 159 100 142 89 17 11 121 76 38 24 159
purH IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) 31 19 128 81 88 55 71 45 20 13 139 87 142 89 17 11 121 76 38 24 159
purN Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) 31 19 128 81 88 55 71 45 20 13 139 87 142 89 17 11 121 76 38 24 159
cydA Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) 31 20 127 80 87 55 71 45 20 13 138 87 141 89 17 11 120 76 38 24 158
gidA tRNA-5-carboxymethylaminomethyl-2-thiouridine(34) synthesis protein MnmG 31 20 127 80 88 56 70 44 20 13 138 87 141 89 17 11 120 76 38 24 158
purB Adenylosuccinate lyase (EC 4.3.2.2) @ SAICAR lyase (EC 4.3.2.2) 30 19 127 81 86 55 71 45 20 13 137 87 140 89 17 11 119 76 38 24 157
SP_0121 Ribonuclease J1 (endonuclease and 5’ exonuclease) 31 20 125 80 87 56 69 44 20 13 136 87 139 89 17 11 118 76 38 24 156
SP_0494 CTP synthase (EC 6.3.4.2) 31 20 125 80 86 55 70 45 20 13 136 87 139 89 17 11 118 76 38 24 156
fba Fructose-bisphosphate aldolase class II (EC 4.1.2.13) 31 20 124 80 85 55 70 45 20 13 135 87 138 89 17 11 117 75 38 25 155
glnA Glutamine synthetase type I (EC 6.3.1.2) 30 19 125 81 86 55 69 45 20 13 135 87 138 89 17 11 117 75 38 25 155
rpoE DNA-directed RNA polymerase delta subunit (EC 2.7.7.6) 31 20 124 80 85 55 70 45 20 13 135 87 138 89 17 11 117 75 38 25 155
atmB Methionine ABC transporter substrate-binding protein 29 19 123 81 83 55 69 45 20 13 132 87 135 89 17 11 114 75 38 25 152
ccpA Catabolite control protein A 30 20 122 80 82 54 70 46 20 13 132 87 135 89 17 11 114 75 38 25 152
luxS S-ribosylhomocysteine lyase (EC 4.4.1.21) @ Autoinducer-2 production protein LuxS 30 20 122 80 84 55 68 45 20 13 132 87 135 89 17 11 114 75 38 25 152
SP_0320 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127) @ 2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) 29 19 123 81 85 56 67 44 10 07 142 93 135 89 17 11 114 75 38 25 152
clpP ATP-dependent Clp protease proteolytic subunit ClpP (EC 3.4.21.92) 30 20 121 80 83 55 68 45 20 13 131 87 134 89 17 11 113 75 38 25 151
Spy_1633   29 19 122 81 83 55 68 45 20 13 131 87 134 89 17 11 113 75 38 25 151
vick  Histidine kinase 29 19 120 81 81 54 68 46 20 13 129 87 132 89 17 11 111 74 38 26 149
SP_2086 Phosphate ABC transporter, permease protein PstA (TC 3.A.1.7.1) 29 20 119 80 81 55 67 45 20 14 128 86 131 89 17 11 110 74 38 26 148
SP_0095 Rhodanese domain protein UPF0176, Firmicutes subgroup 30 21 115 79 82 57 63 43 20 14 125 86 128 88 17 12 107 74 38 26 145
lepA Translation elongation factor LepA 30 21 114 79 79 55 65 45 20 14 124 86 130 90 14 10 107 74 37 26 144
sodA Superoxide dismutase [Mn] (EC 1.15.1.1) 30 21 114 79 81 56 63 44 20 14 124 86 127 88 17 12 106 74 38 26 144
cpsY Methionine biosynthesis and transport regulator MtaR, LysR family 30 21 110 79 79 56 61 44 20 14 120 86 126 90 14 10 103 74 37 26 140
SP_0829 Phosphopentomutase (EC 5.4.2.7) 30 21 110 79 79 56 61 44 20 14 120 86 126 90 14 10 103 74 37 26 140
ciaR Two component system response regulator CiaR 29 21 110 79 78 56 61 44 19 14 120 86 123 88 16 12 103 74 36 26 139
SP_0916 Arginine decarboxylase (EC 4.1.1.19) 30 22 109 78 79 57 60 43 20 14 119 86 124 89 15 11 102 73 37 27 139
guaA GMP synthase [glutamine-hydrolyzing], amidotransferase subunit (EC 6.3.5.2) / GMP synthase [glutamine-hydrolyzing], ATP pyrophosphatase subunit (EC 6.3.5.2) 28 20 110 80 77 56 61 44 19 14 119 86 123 89 15 11 102 74 36 26 138
SP_1970 Aspartate–ammonia ligase (EC 6.3.1.1) 30 22 108 78 78 57 60 43 20 14 118 86 124 90 14 10 102 74 36 26 138
SP_1396 Phosphate ABC transporter, ATP-binding protein PstB (TC 3.A.1.7.1) 28 21 108 79 76 56 60 44 19 14 117 86 120 88 16 12 101 74 35 26 136
SP_1398 Phosphate ABC transporter, permease protein PstA (TC 3.A.1.7.1) 28 21 108 79 76 56 60 44 19 14 117 86 120 88 16 12 101 74 35 26 136
SP_0856 Branched-chain amino acid aminotransferase (EC 2.6.1.42) 28 21 107 79 76 56 59 44 18 13 117 87 121 90 14 10 100 74 35 26 135
SP_1780 Oligoendopeptidase F-like protein 4 22 14 78 12 67 6 33 3 17 15 83 15 83 3 17 13 72 5 28 18
cps4L UDP-N-acetyl-L-fucosamine synthase (EC 5.1.3.28) 3 30 7 70 4 40 6 60 1 10 9 90 9 90 1 10 8 80 2 20 10
SpyM3_0013 Cationic amino acid transporter - APC Superfamily 1 11 8 89 5 56 4 44 1 11 8 89 8 89 1 11 8 89 1 11 9
psaC  ABC transporter membrane-spanning permease-manganese transport 0 00 6 100 2 33 4 67 1 17 5 83 5 83 1 17 5 83 1 17 6
hupA Putative DNA-binding protein HU-beta (ACLAME 290) 0 00 2 100 1 50 1 50 20 100 1 50 2 100 0 00 1 50 1 50 2
pbp1A  DD-transpeptidase 0 00 2 100 2 100 0 00 0 00 2 100 2 100 0 00 1 50 1 50 2
polC  DNA polymerase III PolC-type 1 50 1 50 2 100 0 00 0 00 2 100 2 100 0 00 2 100 0 00 2
fbp54 Fibronectin/fibrinogen-binding protein 0 00 1 100 0 00 1 100 0 00 1 100 1 100 0 00 1 100 0 00 1
glnP Glutamine ABC transporter, substrate-binding protein GlnH / Glutamine ABC transporter, substrate-binding protein GlnH / Glutamine ABC transporter, permease protein GlnP 1 100 0 00 1 100 0 00 1 100 0 00 1 100 0 00 0 00 1 100 1
hasA  Hyaluronan synthase 0 00 1 100 1 100 0 00 0 00 1 100 1 100 0 00 1 100 0 00 1
neuB  Putative N-acetylneuraminic acid synthase 0 00 1 100 1 100 0 00 0 00 1 100 0 00 1 100 1 100 0 00 1
nox  NADH oxidase 0 00 1 100 0 00 1 100 0 00 1 100 1 100 0 00 1 100 0 00 1
pepC Aminopeptidase C (EC 3.4.22.40) 0 00 1 100 0 00 1 100 20 200 1 100 1 100 0 00 1 100 0 00 1
purL Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) 0 00 1 100 1 100 0 00 0 00 1 100 1 100 0 00 1 100 0 00 1
SP_0842   0 00 1 100 1 100 0 00 0 00 1 100 0 00 1 100 1 100 0 00 1
SP_1399 Phosphate ABC transporter, permease protein PstC (TC 3.A.1.7.1) 0 00 1 100 1 100 0 00 0 00 1 100 1 100 0 00 1 100 0 00 1