Table 1 Substrate specificity
Substrate | Relative activity |
|---|---|
dThd | 100 |
Triflurothymidine (TFT) | 80.0 |
Azidothymidine (AZT) | 51.8 |
2′-deoxy-3′-fluorothymidine (FLT) | 33.5 |
α-dThd | 5.1 |
Dideoxythymidine (D4T) | 4.1 |
dUrd | 146 |
5-fluorodeoxyuridine (5FdU) | 122 |
2′-deoxy-2′-fluoro-arabinofuranosyl-5-methyluracil (FMAU) | 47.2 |
D-FMAU | 65.5 |
L-FMAU | 20.4 |
5-Bromovinyl-deoxyuridine (BvdU) | 6.8 |
Uridine | 0.9 |
dCyd | < 0.01 |
dAdo | < 0.01 |
dGuo | 0.2 |