Table 2 Up-regulated genes in the comparisons Supplemented not Infected vs Control not Infected

INHBA

Inhibin subunit beta A

Gamete generation (GO:0007276);

Developmental process involved in reproduction (GO:0003006);

First menstruation in humans

2.5

FST

Follistatin

Gamete generation (GO:0007276);

Developmental process involved in reproduction (GO:0003006);

Body height (Dbgap – Ncbi).

5.8

HSD17B1

hydroxysteroid 17-beta dehydrogenase

Estrogen biosynthesis process (GO:0006703);

Estrogen metabolic process (GO:0008210);

Cell hormonal metabolism process (GO:0034754)

6.4

EZH2

enhancer of zeste 2 polycomb repressive complex 2 subunit

Repression of the transcription (GO:0098532);

G2M checkpoint (Hallmark)

1.8

FBXO5

F-BOX protein 5

Spindle assembly involved in female meiosis (GO:0007057);

Negative regulation of DNA endoreduplication (GO:0032876)

2.7

AURKA

Aurora kinase

Oocyte meiosis (hsa04114); Positive regulation of oocyte maturation (GO:1900195);

Spindle assembly involved in female meiosis I (GO:0007057)

1.9

PLK1

Polo like kinase 1

Oocyte meiosis (hsa04114); Progesterone-mediated oocyte maturation (hsa04914);

Mitotic spindle assembly checkpoint GO:0007094)

2.1

SMC1B

Structural maintenance of chromosomes 1B

Oocyte meiosis (hsa04114)

Sister chromatid segregation (GO:000081)

Nuclear chromosome segregation (GO:0098813)

2.4

FIGLA

Folliculogenesis specific basic helix-loop-helix transcription factor

Oocyte development (GO:0048599);

Oocyte differentiation (GO:0009994);

Oogenesis (GO:0048477)

11

NOBOX

Oogenesis homeobox

Female gamete generation (GO:0048477);

Germ cell development (GO:0007292);

11

MAEL

Maelstrom spermatogenic transposon silencer

DNA methylation involved in gamete generation (GO:0043046)

Synapsis (GO:0007129)

8.7

REC8

REC8 meiotic recombination protein

Oocyte maturation (GO:0001556);

Synaptonemal complex assembly (GO:0007130);

Seminiferous tubule development (GO:0072520)

4.2

BRINP2

BMP/retinoic acid inducible neural specific 2

Cellular response to retinoic acid (GO:0071300);

Response to retinoic acid (GO:0032526)

2.4

CDC20

Cell division cycle 20

Oocyte meiosis (hsa04114);

Mitotic spindle assembly checkpoint (GO:0007094)

1.9

NPM2

Nucleophosmin/nucleoplasmin 2

Positive regulation of meiotic nuclear division (GO:0045836);

Positive regulation of meiotic cell cycle (GO:0051446)

7.4

MND1

Meiotic nuclear divisions 1

Reciprocal meiotic recombination (GO:0007131)

Meiosis I (GO:0007127);

Homologous recombination (GO:0035825)

2.1

REC114

REC114 meiotic recombination

DNA recombination

(GO:0006310);

Meiotic cell cycle (GO:0051321)

3

CENPT

Centromere protein T

Kinetochore assembly (GO:0051382);

Cenp-A containing nucleosome assembly (GO:0034080)

2.1

NCAPH2

Non-SMC condensin II complex subunit

Female meiosis chromosome separation (GO:0051309);

Female meiosis chromosome segregation (GO:0016321);

Meiotic chromosome condensation (GO:0010032).

1.5

PSMC3IP

PSMC3 interacting protein

Reciprocal meiotic recombination (GO:0007131);

Meiosis I (GO:0007127);

Homologous recombination (GO:0035825)

2.1

TRIP13

Thyroid hormone receptor interactor 13

Meiotic recombination checkpoint (GO:0051598)

1.9

SMC1B

Structural maintenance of chromosomes 1B

Oocyte meiosis (hsa04114);

Sister chromatid segregation (GO:0000819)

2.4

MOV10L1

Mov10 like RISC complex RNA helicase 1

DNA methylation involved in gamete generation (GO:0043046)

Male meiosis I (GO:0007141)

3.9

DDX4

Dead-box helicase

DNA methylation involved in gamete generation (GO:0043046);

Hallmark spermatogenesis(M5951);

Male meiosis I (GO:0007141)

1.3

BLM

BLM RecQ like helicase

Homologous recombination (hsa03440)

2.1

CENPS

Centromere protein S

Resolution of meiotic recombination intermediates

(GO:0000712);

DNA replication-independent nucleosome assembly (GO:0006336)

1.6

XRCC3

X-ray repair cross complementing

Homologous recombination (Hsa03440);

Hallmark estrogen response late(M5907)

2.1

FANCD2

FA complementation group D2

Double-strand break repair involved in meiotic recombination (GO:1990918)

1.8

CDC42

Coiled-coil domain containing 42

GO:0048515 Spermatid differentiation

10

BUB1

BUB1 mitotic checkpoint serine/threonine kinase

Meiotic sister chromatid cohesion, centromeric (GO:0051754);

Oocyte meiosis (Hsa04114);

Progesterone-mediated oocyte maturation (hsa04914);

Hallmark spermatogenesis(M5951);

Hallmark MTORC1 signaling(M5924)

1.8

LHX8

LIM homeobox 8

Female gonad development (GO:0008585)

10

NOBOX

NOBOX oogenesis homeobox

Female gamete generation (GO:0007292);

Germ cell development (GO:0007281)

11

SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

Oocyte differentiation

(GO:0009994);

Oogenesis (GO:0048477);

Spermatogenesis (GO:0007283)

8.5

Foxl2

forkhead box L2

Positive regulation of gonadotropin secretion (GO:0032278)

4.8

FSHR

Receptor for follicle stimulating hormone

Cellular response to follicle-stimulating hormone stimulus (GO:0071372);

Ovarian follicle development (GO:0001541)

2.9

PGR

Progesterone receptor

Progesterone receptor signaling pathway (GO:0050847);

Progesterone-mediated oocyte maturation (hsa04914); Oocyte meiosis (hsa04114)

1.1

STAR

Steroidogenic acute regulatory protein

Circadian sleep/wake cycle, REM sleep (GO:0042747);

Ovarian steroidogenesis (hsa04913)

2.2

CYP17A1

Cytochrome P450 family 17 subfamily A member 1

Progesterone metabolic process (GO:0042448)

4.1

CYP11A1

Cytochrome P450 family 11 subfamily A member 1

GO:0006700 C21-steroid hormone biosynthetic process;

Ovarian steroidogenesis (hsa04913)

2.4

CYP19A1

Cytochrome P450 family 19 subfamily A member 1

Positive regulation of estradiol secretion (GO:2000866); Negative regulation of macrophage chemotaxis (GO:0010760)

9.5

ESR2

Estrogen receptor 2

Intracellular estrogen receptor signaling pathway (GO:0030520)

2.7

INHBA

Inhibin subunit beta A

Negative regulation of follicle-stimulating hormone secretion (GO:0046882);

Positive regulation of follicle-stimulating hormone secretion (GO:0046881)

2.5

LHCGR

Luteinizing hormone/choriogonadotropin receptor

Cellular response to luteinizing hormone stimulus (GO:0071373)

1.3

VEGF-A

Vascular endothelial growth factor A

VEGF signaling pathway (hsa04370)

2.5