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Table 2 Up-regulated genes in the comparisons Supplemented not Infected vs Control not Infected

From: Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets

Gene ID Gene name /Function GO/Biological processes/Pathways Log fold change
INHBA Inhibin subunit beta A Gamete generation (GO:0007276);
Developmental process involved in reproduction (GO:0003006);
First menstruation in humans
2.5
FST Follistatin Gamete generation (GO:0007276);
Developmental process involved in reproduction (GO:0003006);
Body height (Dbgap – Ncbi).
5.8
HSD17B1 hydroxysteroid 17-beta dehydrogenase Estrogen biosynthesis process (GO:0006703);
Estrogen metabolic process (GO:0008210);
Cell hormonal metabolism process (GO:0034754)
6.4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit Repression of the transcription (GO:0098532);
G2M checkpoint (Hallmark)
1.8
FBXO5 F-BOX protein 5 Spindle assembly involved in female meiosis (GO:0007057);
Negative regulation of DNA endoreduplication (GO:0032876)
2.7
AURKA Aurora kinase Oocyte meiosis (hsa04114); Positive regulation of oocyte maturation (GO:1900195);
Spindle assembly involved in female meiosis I (GO:0007057)
1.9
PLK1 Polo like kinase 1 Oocyte meiosis (hsa04114); Progesterone-mediated oocyte maturation (hsa04914);
Mitotic spindle assembly checkpoint GO:0007094)
2.1
SMC1B Structural maintenance of chromosomes 1B Oocyte meiosis (hsa04114)
Sister chromatid segregation (GO:000081)
Nuclear chromosome segregation (GO:0098813)
2.4
FIGLA Folliculogenesis specific basic helix-loop-helix transcription factor Oocyte development (GO:0048599);
Oocyte differentiation (GO:0009994);
Oogenesis (GO:0048477)
11
NOBOX Oogenesis homeobox Female gamete generation (GO:0048477);
Germ cell development (GO:0007292);
11
MAEL Maelstrom spermatogenic transposon silencer DNA methylation involved in gamete generation (GO:0043046)
Synapsis (GO:0007129)
8.7
REC8 REC8 meiotic recombination protein Oocyte maturation (GO:0001556);
Synaptonemal complex assembly (GO:0007130);
Seminiferous tubule development (GO:0072520)
4.2
BRINP2 BMP/retinoic acid inducible neural specific 2 Cellular response to retinoic acid (GO:0071300);
Response to retinoic acid (GO:0032526)
2.4
CDC20 Cell division cycle 20 Oocyte meiosis (hsa04114);
Mitotic spindle assembly checkpoint (GO:0007094)
1.9
NPM2 Nucleophosmin/nucleoplasmin 2 Positive regulation of meiotic nuclear division (GO:0045836);
Positive regulation of meiotic cell cycle (GO:0051446)
7.4
MND1 Meiotic nuclear divisions 1 Reciprocal meiotic recombination (GO:0007131)
Meiosis I (GO:0007127);
Homologous recombination (GO:0035825)
2.1
REC114 REC114 meiotic recombination DNA recombination
(GO:0006310);
Meiotic cell cycle (GO:0051321)
3
CENPT Centromere protein T Kinetochore assembly (GO:0051382);
Cenp-A containing nucleosome assembly (GO:0034080)
2.1
NCAPH2 Non-SMC condensin II complex subunit Female meiosis chromosome separation (GO:0051309);
Female meiosis chromosome segregation (GO:0016321);
Meiotic chromosome condensation (GO:0010032).
1.5
PSMC3IP PSMC3 interacting protein Reciprocal meiotic recombination (GO:0007131);
Meiosis I (GO:0007127);
Homologous recombination (GO:0035825)
2.1
TRIP13 Thyroid hormone receptor interactor 13 Meiotic recombination checkpoint (GO:0051598) 1.9
SMC1B Structural maintenance of chromosomes 1B Oocyte meiosis (hsa04114);
Sister chromatid segregation (GO:0000819)
2.4
MOV10L1 Mov10 like RISC complex RNA helicase 1 DNA methylation involved in gamete generation (GO:0043046)
Male meiosis I (GO:0007141)
3.9
DDX4 Dead-box helicase DNA methylation involved in gamete generation (GO:0043046);
Hallmark spermatogenesis(M5951);
Male meiosis I (GO:0007141)
1.3
BLM BLM RecQ like helicase Homologous recombination (hsa03440) 2.1
CENPS Centromere protein S Resolution of meiotic recombination intermediates
(GO:0000712);
DNA replication-independent nucleosome assembly (GO:0006336)
1.6
XRCC3 X-ray repair cross complementing Homologous recombination (Hsa03440);
Hallmark estrogen response late(M5907)
2.1
FANCD2 FA complementation group D2 Double-strand break repair involved in meiotic recombination (GO:1990918) 1.8
CDC42 Coiled-coil domain containing 42 GO:0048515 Spermatid differentiation 10
BUB1 BUB1 mitotic checkpoint serine/threonine kinase Meiotic sister chromatid cohesion, centromeric (GO:0051754);
Oocyte meiosis (Hsa04114);
Progesterone-mediated oocyte maturation (hsa04914);
Hallmark spermatogenesis(M5951);
Hallmark MTORC1 signaling(M5924)
1.8
LHX8 LIM homeobox 8 Female gonad development (GO:0008585) 10
NOBOX NOBOX oogenesis homeobox Female gamete generation (GO:0007292);
Germ cell development (GO:0007281)
11
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 Oocyte differentiation
(GO:0009994);
Oogenesis (GO:0048477);
Spermatogenesis (GO:0007283)
8.5
Foxl2 forkhead box L2 Positive regulation of gonadotropin secretion (GO:0032278) 4.8
FSHR Receptor for follicle stimulating hormone Cellular response to follicle-stimulating hormone stimulus (GO:0071372);
Ovarian follicle development (GO:0001541)
2.9
PGR Progesterone receptor Progesterone receptor signaling pathway (GO:0050847);
Progesterone-mediated oocyte maturation (hsa04914); Oocyte meiosis (hsa04114)
1.1
STAR Steroidogenic acute regulatory protein Circadian sleep/wake cycle, REM sleep (GO:0042747);
Ovarian steroidogenesis (hsa04913)
2.2
CYP17A1 Cytochrome P450 family 17 subfamily A member 1 Progesterone metabolic process (GO:0042448) 4.1
CYP11A1 Cytochrome P450 family 11 subfamily A member 1 GO:0006700 C21-steroid hormone biosynthetic process;
Ovarian steroidogenesis (hsa04913)
2.4
CYP19A1 Cytochrome P450 family 19 subfamily A member 1 Positive regulation of estradiol secretion (GO:2000866); Negative regulation of macrophage chemotaxis (GO:0010760) 9.5
ESR2 Estrogen receptor 2 Intracellular estrogen receptor signaling pathway (GO:0030520) 2.7
INHBA Inhibin subunit beta A Negative regulation of follicle-stimulating hormone secretion (GO:0046882);
Positive regulation of follicle-stimulating hormone secretion (GO:0046881)
2.5
LHCGR Luteinizing hormone/choriogonadotropin receptor Cellular response to luteinizing hormone stimulus (GO:0071373) 1.3
VEGF-A Vascular endothelial growth factor A VEGF signaling pathway (hsa04370) 2.5