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Table 1 Up-regulated genes in the comparison Supplemented Infected vs Control Infected

From: Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets

Gene ID Gene name /Function GO/Biological processes/Pathways Log fold change
INHBA Inhibin subunit beta A Gamete generation (GO:0007276);
Developmental process involved in reproduction (GO:0003006);
First menstruation in humans
5.1
FST Follistatin Gamete generation (GO:0007276);
Developmental process involved in reproduction (GO:0003006);
Body height (Dbgap – Ncbi).
3.5
HSD17B1 Hydroxysteroid 17-beta dehydrogenase Estrogen biosynthesis process (GO:0006703);
Estrogen metabolic process (GO:0008210);
Cell hormonal metabolism process (GO:0034754)
1.3
EZH2 Enhancer of zeste 2 polycomb repressive complex 2 subunit Repression of the transcription (GO:0098532);
G2M checkpoint (Hallmark)
1.2
FBXO5 F-BOX protein 5 Spindle assembly involved in female meiosis (GO:0007057);
Negative regulation of DNA endoreduplication (GO:0032876)
1.6
AURKA Aurora kinase Oocyte meiosis (hsa04114); Positive regulation of oocyte maturation (GO:1900195);
Spindle assembly involved in female meiosis I (GO:0007057)
1.6
PLK1 Polo like kinase 1 Oocyte meiosis (hsa04114); Progesterone-mediated oocyte maturation (hsa04914);
Mitotic spindle assembly checkpoint GO:0007094)
1.3
SMC1B Structural maintenance of chromosomes 1B Oocyte meiosis (hsa04114)
Sister chromatid segregation (GO:000081)
Nuclear chromosome segregation (GO:0098813)
1.9
FIGLA Folliculogenesis specific basic helix-loop-helix transcription factor Oocyte development (GO:0048599);
Oocyte differentiation (GO:0009994);
Oogenesis (GO:0048477)
2.1
MAEL Maelstrom spermatogenic transposon silencer DNA methylation involved in gamete generation (GO:0043046)
Synapsis (GO:0007129)
1.6
REC8 REC8 meiotic recombination protein Oocyte maturation (GO:0001556);
Synaptonemal complex assembly (GO:0007130);
Seminiferous tubule development (GO:0072520)
1.4
BRINP2 BMP/retinoic acid inducible neural specific 2 Cellular response to retinoic acid (GO:0071300);
Response to retinoic acid (GO:0032526)
1.2
CDC20 Cell division cycle 20 Oocyte meiosis (hsa04114);
Mitotic spindle assembly checkpoint (GO:0007094)
1.7
NPM2 Nucleophosmin/nucleoplasmin 2 Positive regulation of meiotic nuclear division (GO:0045836);
Positive regulation of meiotic cell cycle (GO:0051446)
2.3
MND1 Meiotic nuclear divisions 1 Reciprocal meiotic recombination (GO:0007131)
Meiosis I (GO:0007127);
Homologous recombination (GO:0035825)
1.4
REC114 REC114 meiotic recombination DNA recombination
(GO:0006310);
Meiotic cell cycle (GO:0051321)
3.4
CENPT Centromere protein T Kinetochore assembly (GO:0051382);
Cenp-A containing nucleosome assembly (GO:0034080)
3.4
CDC16 Cell division cycle 16 Progesterone-mediated oocyte maturation (hsa04914); Oocyte meiosis (hsa04114) 1.2
CDC25C Cell division cycle 25C Positive regulation of G2/Mi transition of meiotic cell cycle (GO:0110032);
Oocyte meiosis (hsa04114);
Progesterone-mediated oocyte maturation((hsa04914)
1.3
NCAPH2 Non-SMC condensin II complex subunit Female meiosis chromosome separation (GO:0051309);
Female meiosis chromosome segregation (GO:0016321);
Meiotic chromosome condensation (GO:0010032).
1.4
PSMC3IP PSMC3 interacting protein Reciprocal meiotic recombination (GO:0007131);
Meiosis I (GO:0007127);
Homologous recombination (GO:0035825)
2.1
TRIP13 Thyroid hormone receptor interactor 13 Meiotic recombination checkpoint (GO:0051598) 1.9
SMCB1 Structural maintenance of chromosomes 1B Oocyte meiosis (hsa04114);
Sister chromatid segregation (GO:0000819)
2.4
MOV10L1 Mov10 like RISC complex RNA helicase 1 DNA methylation involved in gamete generation (GO:0043046)
Male meiosis I (GO:0007141)
3.9
DDX4 Dead-box helicase DNA methylation involved in gamete generation (GO:0043046);
Hallmark spermatogenesis(M5951);
Male meiosis I (GO:0007141)
1.3
BLM BLM RecQ like helicase Homologous recombination (hsa03440) 2.1
CENPS Centromere protein S Resolution of meiotic recombination intermediates
(GO:0000712);
DNA replication-independent nucleosome assembly (GO:0006336)
1.6
XRCC3 X-ray repair cross complementing Homologous recombination (Hsa03440);
Hallmark estrogen response late(M5907)
2.1
ANKRD31 Ankyrin repeat domain 31 Meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (GO:0010780)
Positive regulation of meiotic DNA double-strand break formation (GO:1903343);
Body weights and measures (Dbgap-Ncbi)
1.7
FANCD2 FA complementation group D2 Double-strand break repair involved in meiotic recombination (GO:1990918) 1.8
CDC42 Coiled-coil domain containing 42 GO:0048515 Spermatid differentiation 10
BUB1 BUB1 mitotic checkpoint serine/threonine kinase Meiotic sister chromatid cohesion, centromeric (GO:0051754);
Oocyte meiosis (Hsa04114);
Progesterone-mediated oocyte maturation (hsa04914);
Hallmark spermatogenesis(M5951);
Hallmark MTORC1 signaling(M5924)
1.8
NUCB2 Nucleobinding 2 Negative regulation of appetite (GO:0032099);
Negative regulation of response to food (GO:0032096);
Negative regulation of response to nutrient level (GO:0032108)
1.4
CLPSL2 Colipase like 2 Response to food (GO:0032094);
Digestion (GO:0007586);
Lipid catabolic process (GO:0016042)
1.3
CYP19A1 Cytochrome P450 family 19 subfamily A member 1 Positive regulation of estradiol secretion (GO:2000866); Negative regulation of macrophage chemotaxis (GO:0010760) 3.6
VEGF-A Vascular endothelial growth factor A VEGF signaling pathway (hsa04370) 2.2
BRIP1 BRCA1 interacting protein C-terminal helicase 1 Meiotic DNA double strand break process involved in reciprocal meiotic recombination (GO:0010705);
Chiasma assembly (GO:0051026);
Spermatogonial cell division (GO:0007284);
Homologous recombination (Hsa03440)
2
RBBP8 RB binding protein 8 DNA double-strand break processing involved in repair via single-strand annealing (GO:0010792);
Homologous recombination (Hsa03440)
2
GAST Gastrin Response to food (GO:0032094);
Response to nutrient levels (GO:0031667)
Response to extracellular stimulus (GO:0009991)
Gastric acid secretion (hsa04971)
4.6
LRCOL1 Leucine rich colipase like Response to food (GO:0032094);
Digestion (GO:0007586);
Lipid catabolic process (GO:0016042)
10