Table 1 Up-regulated genes in the comparison Supplemented Infected vs Control Infected

INHBA

Inhibin subunit beta A

Gamete generation (GO:0007276);

Developmental process involved in reproduction (GO:0003006);

First menstruation in humans

5.1

FST

Follistatin

Gamete generation (GO:0007276);

Developmental process involved in reproduction (GO:0003006);

Body height (Dbgap – Ncbi).

3.5

HSD17B1

Hydroxysteroid 17-beta dehydrogenase

Estrogen biosynthesis process (GO:0006703);

Estrogen metabolic process (GO:0008210);

Cell hormonal metabolism process (GO:0034754)

1.3

EZH2

Enhancer of zeste 2 polycomb repressive complex 2 subunit

Repression of the transcription (GO:0098532);

G2M checkpoint (Hallmark)

1.2

FBXO5

F-BOX protein 5

Spindle assembly involved in female meiosis (GO:0007057);

Negative regulation of DNA endoreduplication (GO:0032876)

1.6

AURKA

Aurora kinase

Oocyte meiosis (hsa04114); Positive regulation of oocyte maturation (GO:1900195);

Spindle assembly involved in female meiosis I (GO:0007057)

1.6

PLK1

Polo like kinase 1

Oocyte meiosis (hsa04114); Progesterone-mediated oocyte maturation (hsa04914);

Mitotic spindle assembly checkpoint GO:0007094)

1.3

SMC1B

Structural maintenance of chromosomes 1B

Oocyte meiosis (hsa04114)

Sister chromatid segregation (GO:000081)

Nuclear chromosome segregation (GO:0098813)

1.9

FIGLA

Folliculogenesis specific basic helix-loop-helix transcription factor

Oocyte development (GO:0048599);

Oocyte differentiation (GO:0009994);

Oogenesis (GO:0048477)

2.1

MAEL

Maelstrom spermatogenic transposon silencer

DNA methylation involved in gamete generation (GO:0043046)

Synapsis (GO:0007129)

1.6

REC8

REC8 meiotic recombination protein

Oocyte maturation (GO:0001556);

Synaptonemal complex assembly (GO:0007130);

Seminiferous tubule development (GO:0072520)

1.4

BRINP2

BMP/retinoic acid inducible neural specific 2

Cellular response to retinoic acid (GO:0071300);

Response to retinoic acid (GO:0032526)

1.2

CDC20

Cell division cycle 20

Oocyte meiosis (hsa04114);

Mitotic spindle assembly checkpoint (GO:0007094)

1.7

NPM2

Nucleophosmin/nucleoplasmin 2

Positive regulation of meiotic nuclear division (GO:0045836);

Positive regulation of meiotic cell cycle (GO:0051446)

2.3

MND1

Meiotic nuclear divisions 1

Reciprocal meiotic recombination (GO:0007131)

Meiosis I (GO:0007127);

Homologous recombination (GO:0035825)

1.4

REC114

REC114 meiotic recombination

DNA recombination

(GO:0006310);

Meiotic cell cycle (GO:0051321)

3.4

CENPT

Centromere protein T

Kinetochore assembly (GO:0051382);

Cenp-A containing nucleosome assembly (GO:0034080)

3.4

CDC16

Cell division cycle 16

Progesterone-mediated oocyte maturation (hsa04914); Oocyte meiosis (hsa04114)

1.2

CDC25C

Cell division cycle 25C

Positive regulation of G2/Mi transition of meiotic cell cycle (GO:0110032);

Oocyte meiosis (hsa04114);

Progesterone-mediated oocyte maturation((hsa04914)

1.3

NCAPH2

Non-SMC condensin II complex subunit

Female meiosis chromosome separation (GO:0051309);

Female meiosis chromosome segregation (GO:0016321);

Meiotic chromosome condensation (GO:0010032).

1.4

PSMC3IP

PSMC3 interacting protein

Reciprocal meiotic recombination (GO:0007131);

Meiosis I (GO:0007127);

Homologous recombination (GO:0035825)

2.1

TRIP13

Thyroid hormone receptor interactor 13

Meiotic recombination checkpoint (GO:0051598)

1.9

SMCB1

Structural maintenance of chromosomes 1B

Oocyte meiosis (hsa04114);

Sister chromatid segregation (GO:0000819)

2.4

MOV10L1

Mov10 like RISC complex RNA helicase 1

DNA methylation involved in gamete generation (GO:0043046)

Male meiosis I (GO:0007141)

3.9

DDX4

Dead-box helicase

DNA methylation involved in gamete generation (GO:0043046);

Hallmark spermatogenesis(M5951);

Male meiosis I (GO:0007141)

1.3

BLM

BLM RecQ like helicase

Homologous recombination (hsa03440)

2.1

CENPS

Centromere protein S

Resolution of meiotic recombination intermediates

(GO:0000712);

DNA replication-independent nucleosome assembly (GO:0006336)

1.6

XRCC3

X-ray repair cross complementing

Homologous recombination (Hsa03440);

Hallmark estrogen response late(M5907)

2.1

ANKRD31

Ankyrin repeat domain 31

Meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (GO:0010780)

Positive regulation of meiotic DNA double-strand break formation (GO:1903343);

Body weights and measures (Dbgap-Ncbi)

1.7

FANCD2

FA complementation group D2

Double-strand break repair involved in meiotic recombination (GO:1990918)

1.8

CDC42

Coiled-coil domain containing 42

GO:0048515 Spermatid differentiation

10

BUB1

BUB1 mitotic checkpoint serine/threonine kinase

Meiotic sister chromatid cohesion, centromeric (GO:0051754);

Oocyte meiosis (Hsa04114);

Progesterone-mediated oocyte maturation (hsa04914);

Hallmark spermatogenesis(M5951);

Hallmark MTORC1 signaling(M5924)

1.8

NUCB2

Nucleobinding 2

Negative regulation of appetite (GO:0032099);

Negative regulation of response to food (GO:0032096);

Negative regulation of response to nutrient level (GO:0032108)

1.4

CLPSL2

Colipase like 2

Response to food (GO:0032094);

Digestion (GO:0007586);

Lipid catabolic process (GO:0016042)

1.3

CYP19A1

Cytochrome P450 family 19 subfamily A member 1

Positive regulation of estradiol secretion (GO:2000866); Negative regulation of macrophage chemotaxis (GO:0010760)

3.6

VEGF-A

Vascular endothelial growth factor A

VEGF signaling pathway (hsa04370)

2.2

BRIP1

BRCA1 interacting protein C-terminal helicase 1

Meiotic DNA double strand break process involved in reciprocal meiotic recombination (GO:0010705);

Chiasma assembly (GO:0051026);

Spermatogonial cell division (GO:0007284);

Homologous recombination (Hsa03440)

2

RBBP8

RB binding protein 8

DNA double-strand break processing involved in repair via single-strand annealing (GO:0010792);

Homologous recombination (Hsa03440)

2

GAST

Gastrin

Response to food (GO:0032094);

Response to nutrient levels (GO:0031667)

Response to extracellular stimulus (GO:0009991)

Gastric acid secretion (hsa04971)

4.6

LRCOL1

Leucine rich colipase like

Response to food (GO:0032094);

Digestion (GO:0007586);

Lipid catabolic process (GO:0016042)

10