Table 1 Up-regulated genes in the comparison Supplemented Infected vs Control Infected
| Gene ID | Gene name /Function | GO/Biological processes/Pathways | Log fold change |
|---|---|---|---|
| INHBA | Inhibin subunit beta A |
Gamete generation (GO:0007276); Developmental process involved in reproduction (GO:0003006); First menstruation in humans | 5.1 |
| FST | Follistatin |
Gamete generation (GO:0007276); Developmental process involved in reproduction (GO:0003006); Body height (Dbgap – Ncbi). | 3.5 |
| HSD17B1 | Hydroxysteroid 17-beta dehydrogenase |
Estrogen biosynthesis process (GO:0006703); Estrogen metabolic process (GO:0008210); Cell hormonal metabolism process (GO:0034754) | 1.3 |
| EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit |
Repression of the transcription (GO:0098532); G2M checkpoint (Hallmark) | 1.2 |
| FBXO5 | F-BOX protein 5 |
Spindle assembly involved in female meiosis (GO:0007057); Negative regulation of DNA endoreduplication (GO:0032876) | 1.6 |
| AURKA | Aurora kinase |
Oocyte meiosis (hsa04114); Positive regulation of oocyte maturation (GO:1900195); Spindle assembly involved in female meiosis I (GO:0007057) | 1.6 |
| PLK1 | Polo like kinase 1 |
Oocyte meiosis (hsa04114); Progesterone-mediated oocyte maturation (hsa04914); Mitotic spindle assembly checkpoint GO:0007094) | 1.3 |
| SMC1B | Structural maintenance of chromosomes 1B |
Oocyte meiosis (hsa04114) Sister chromatid segregation (GO:000081) Nuclear chromosome segregation (GO:0098813) | 1.9 |
| FIGLA | Folliculogenesis specific basic helix-loop-helix transcription factor |
Oocyte development (GO:0048599); Oocyte differentiation (GO:0009994); Oogenesis (GO:0048477) | 2.1 |
| MAEL | Maelstrom spermatogenic transposon silencer |
DNA methylation involved in gamete generation (GO:0043046) Synapsis (GO:0007129) | 1.6 |
| REC8 | REC8 meiotic recombination protein |
Oocyte maturation (GO:0001556); Synaptonemal complex assembly (GO:0007130); Seminiferous tubule development (GO:0072520) | 1.4 |
| BRINP2 | BMP/retinoic acid inducible neural specific 2 |
Cellular response to retinoic acid (GO:0071300); Response to retinoic acid (GO:0032526) | 1.2 |
| CDC20 | Cell division cycle 20 |
Oocyte meiosis (hsa04114); Mitotic spindle assembly checkpoint (GO:0007094) | 1.7 |
| NPM2 | Nucleophosmin/nucleoplasmin 2 |
Positive regulation of meiotic nuclear division (GO:0045836); Positive regulation of meiotic cell cycle (GO:0051446) | 2.3 |
| MND1 | Meiotic nuclear divisions 1 |
Reciprocal meiotic recombination (GO:0007131) Meiosis I (GO:0007127); Homologous recombination (GO:0035825) | 1.4 |
| REC114 | REC114 meiotic recombination |
DNA recombination (GO:0006310); Meiotic cell cycle (GO:0051321) | 3.4 |
| CENPT | Centromere protein T |
Kinetochore assembly (GO:0051382); Cenp-A containing nucleosome assembly (GO:0034080) | 3.4 |
| CDC16 | Cell division cycle 16 | Progesterone-mediated oocyte maturation (hsa04914); Oocyte meiosis (hsa04114) | 1.2 |
| CDC25C | Cell division cycle 25C |
Positive regulation of G2/Mi transition of meiotic cell cycle (GO:0110032); Oocyte meiosis (hsa04114); Progesterone-mediated oocyte maturation((hsa04914) | 1.3 |
| NCAPH2 | Non-SMC condensin II complex subunit |
Female meiosis chromosome separation (GO:0051309); Female meiosis chromosome segregation (GO:0016321); Meiotic chromosome condensation (GO:0010032). | 1.4 |
| PSMC3IP | PSMC3 interacting protein |
Reciprocal meiotic recombination (GO:0007131); Meiosis I (GO:0007127); Homologous recombination (GO:0035825) | 2.1 |
| TRIP13 | Thyroid hormone receptor interactor 13 | Meiotic recombination checkpoint (GO:0051598) | 1.9 |
| SMCB1 | Structural maintenance of chromosomes 1B |
Oocyte meiosis (hsa04114); Sister chromatid segregation (GO:0000819) | 2.4 |
| MOV10L1 | Mov10 like RISC complex RNA helicase 1 |
DNA methylation involved in gamete generation (GO:0043046) Male meiosis I (GO:0007141) | 3.9 |
| DDX4 | Dead-box helicase |
DNA methylation involved in gamete generation (GO:0043046); Hallmark spermatogenesis(M5951); Male meiosis I (GO:0007141) | 1.3 |
| BLM | BLM RecQ like helicase | Homologous recombination (hsa03440) | 2.1 |
| CENPS | Centromere protein S |
Resolution of meiotic recombination intermediates (GO:0000712); DNA replication-independent nucleosome assembly (GO:0006336) | 1.6 |
| XRCC3 | X-ray repair cross complementing |
Homologous recombination (Hsa03440); Hallmark estrogen response late(M5907) | 2.1 |
| ANKRD31 | Ankyrin repeat domain 31 |
Meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (GO:0010780) Positive regulation of meiotic DNA double-strand break formation (GO:1903343); Body weights and measures (Dbgap-Ncbi) | 1.7 |
| FANCD2 | FA complementation group D2 | Double-strand break repair involved in meiotic recombination (GO:1990918) | 1.8 |
| CDC42 | Coiled-coil domain containing 42 | GO:0048515 Spermatid differentiation | 10 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
Meiotic sister chromatid cohesion, centromeric (GO:0051754); Oocyte meiosis (Hsa04114); Progesterone-mediated oocyte maturation (hsa04914); Hallmark spermatogenesis(M5951); Hallmark MTORC1 signaling(M5924) | 1.8 |
| NUCB2 | Nucleobinding 2 |
Negative regulation of appetite (GO:0032099); Negative regulation of response to food (GO:0032096); Negative regulation of response to nutrient level (GO:0032108) | 1.4 |
| CLPSL2 | Colipase like 2 |
Response to food (GO:0032094); Digestion (GO:0007586); Lipid catabolic process (GO:0016042) | 1.3 |
| CYP19A1 | Cytochrome P450 family 19 subfamily A member 1 | Positive regulation of estradiol secretion (GO:2000866); Negative regulation of macrophage chemotaxis (GO:0010760) | 3.6 |
| VEGF-A | Vascular endothelial growth factor A | VEGF signaling pathway (hsa04370) | 2.2 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 |
Meiotic DNA double strand break process involved in reciprocal meiotic recombination (GO:0010705); Chiasma assembly (GO:0051026); Spermatogonial cell division (GO:0007284); Homologous recombination (Hsa03440) | 2 |
| RBBP8 | RB binding protein 8 |
DNA double-strand break processing involved in repair via single-strand annealing (GO:0010792); Homologous recombination (Hsa03440) | 2 |
| GAST | Gastrin |
Response to food (GO:0032094); Response to nutrient levels (GO:0031667) Response to extracellular stimulus (GO:0009991) Gastric acid secretion (hsa04971) | 4.6 |
| LRCOL1 | Leucine rich colipase like |
Response to food (GO:0032094); Digestion (GO:0007586); Lipid catabolic process (GO:0016042) | 10 |