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Fig. 2 | BMC Veterinary Research

Fig. 2

From: An in vivo pharmacokinetic study of metformin microparticles as an oral sustained release formulation in rabbits

Fig. 2

X-ray diffraction (XRD) spectra for pure metformin, blank microparticles and metformin-loaded microparticles scanned between 5–80° at 5θ. Pure metformin (blue curve) displayed sharp, high-intensity peaks typical of the crystalline drug. The XRD curve of blank PLA microparticles (red curve) shows two very intense peaks characteristic of its semi-crystalline structure. On the other hand, microencapsulation of metformin into the PLA microparticles (green curve) suppressed the sharp peaks of the drug, indicating its amorphous nature in the microparticles

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BMC Veterinary Research

ISSN: 1746-6148

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