Pharmacokinetic parameters | IV | OUT | FS-ODF | P OUT vs. FS-ODF |
---|---|---|---|---|
Cmax (μg/mL) | 9.65 ± 1.63 (10.35) | 0.61 ± 0.31 (0.69) | 0.81 ± 0.81 (0.58) | 0.619 |
Tmax (h) | 0.00 | 1 (0.5-1.5) | 0.75 (0.25-1) | 0.130 |
T1/2 (h) | 2.07 ± 0.76 (1.63) | 3.44 ± 1.79 (2.86) | 2.64 ± 0.75 (2.46) | 0.602 |
MRT (h) | 0.90 ± 0.25 (0.78) | 5.08 ± 1.67 (4.13) | 3.47 ± 0.76 (3.55) | 0.128 |
AUCinf (μg·h/mL) | 2.74 ± 0.25 (2.60) | 1.50 ± 0.73 (1.72) | 1.25 ± 0.68 (1.34) | 0.493 |
AUClast (μg·h/mL) | 2.67 ± 0.26 (2.56) | 1.16 ± 0.46 (1.44) | 1.11 ± 0.63 (1.08) | 0.734 |
CL (mL/h/kg) | 735.7 ± 63.84 (768.98) | - | - | - |
Vss (mL/kg) | 667.5 ± 222.6 (597.82) | - | - | - |
BA (%) | - | 54.98 ± 26.51 (62.74) | 45.73 ± 25.02 (48.82) | 0.493 |