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Fig. 2 | BMC Veterinary Research

Fig. 2

From: Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO

Fig. 2

Ubiquitination analysis of host proteins regulated by B. melitensis UGPase. (A) Venn diagram showing a summary of the number of ubiquitinated proteins identified from different combinations. D.R., Downregulated; U.R., Upregulated. (B) GO enrichment analysis of the downregulated ubiquitinated proteins. The numbers in the Y axes represent the value as determined from the analysis of significance. Values greater than 1.3 indicate p-values lower than 0.05, which means that the data are statistically significant. (C) Heat maps of the biological processes of the identified and quantified proteins. The lowest levels of enrichment are shown in blue, and the highest levels of enrichment are shown in red. (D) High-confidence STRING network of proteins with significantly changed ubiquitination levels. The upregulation (16 M/16 M-UGPase) of proteins with ubiquitination sites is marked red, downregulated (16 M/16 M-UGPase) proteins are in green, and proteins that are both upregulated and downregulated are in yellow

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