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Table 1 Effects of donkey-derived IgG on clinical symptoms of the CDV-infected dogs at the different time

From: Donkey-derived anti-CDV IgG, as a passive immunotherapy agent, can effectively increase survival rates of the experimental CDV-infected dogs

Symptoms

Time after CDV infection (d)

CDV

CDV + Donkey IgG

CDV + Dog IgG

2–3

5–6

8–9

11–12

14–15

2–3

5–6

8–9

11–12

14–15

2–3

5–6

8–9

11–12

14–15

Loss of appetite

+

+++

++

+++

+++

+

++

++

++

+

+

++

++

+

+

Gum in the eyes

–

+++

++

+++

+++

–

++

+

+

–

–

+

+

+

–

Running at the nose

–

+++

++

+++

+++

–

++

+

+

–

–

++

+

+

–

Cough

–

++

+

+++

+++

–

+

+

+

–

–

+

+

–

–

Diarrhea/dehydration

–

++

+

+++

+++

–

+

+

–

–

–

–

+

–

–

Neurologic symptom

–

–

–

++

+++

–

–

–

–

–

–

–

–

–

–

  1. +, ++ and +++ respectively represent the severity of symptoms: mild, moderate and severe