Variables | Distribution | (I) 4–8 wk. (n = 35) | (II) 9–24 wk. (n = 48) | (III) 25–52 wk. (n = 21) | (IV) > 52 wk. (n = 71) | ||||
---|---|---|---|---|---|---|---|---|---|
Mean (SD) Median (IQR) | LL (90% CI) UL (90% CI) | Mean (SD) Median (IQR) | LL (90% CI) UL (90% CI) | Mean (SD) Median (IQR) | LL (90% CI) UL (90% CI) | Mean (SD) Median (IQR) | LL (90% CI) UL (90% CI) | ||
AST (U/L) | G | 39 (9.9) a | 18 (13–23) | 40 (8.6) a | 21 (21–27) | 38 (10.2) a | 16 (11–23) | 38 (9.1) a | 21 (20–24) |
40 (16) | 60 (55–64) | 40 (11) | 57 (54–57) | 38 (15.5) | 60 (53–66) | 37 (16) | 54 (52–54) | ||
ALT (U/L) | NG | 26 (8.8) a | 8 (4–12) | 32 (9.1) b | 15 (14–20) | 37 (7.6) b, c | 25 (24–27) | 44 (12.6) c | 22 (21–26) |
26 (11) | 45 (40–49) | 31 (15.7) | 54 (46–55) | 36 (14.5) | 60 (52–80) | 41 (19) | 70 (65–70) | ||
LDH (U/L) | NG | 244 (164.6) a | 43 (43–48) | 73 (32.4) b | 25 (24–34) | 63 (32) b | 6 (6–13) | 67 (42) b | 9 (8–17) |
166 (228) | 695 (526–861) | 74 (55.5) | 139 (131–140) | 62 (51.5) | 131 (112–150) | 56 (39) | 185 (143–187) | ||
ALP (U/L) | NG | 215 (71.6) a | 101 (91–115) | 193 (39.2) a | 111 (110–123) | 85 (36.7) b | 18 (10–36) | 52 (23.3) c | 15 (15–23) |
186 (96) | 394 (332–456) | 187.5 (58) | 281 (253–286) | 90 (72) | 179 (150–202) | 47 (36) | 112 (92–113) | ||
GGT (U/L) | NG | 5 (1.7) a | 2 (2–3) | 5 (1.3) a | 2 (2–3) | 5 (1.9) a | 2 (0.3–3) | 6 (2.1) a | 2 (2–3) |
5 (2) | 10 (9–12) | 5 (2) | 8 (7–8) | 6 (2) | 9 (8–10) | 6 (4) | 10 (9–10) | ||
Total protein (g/dL) | NG | 4.6 (0.6) a | 3.5 (3.3–3.7) | 5.1 (0.7) b | 4.0 (4.0–4.0) | 5.7 (0.8) b | 4.3 (4.1–4.6) | 6.2 (0.9) c | 4.4 (4.2–4.8) |
4.4 (1.2) | 6.4 (5.8–6.9) | 5.1 (1.1) | 7.1 (6.3–7.3) | 5.5 (1.4) | 7.9 (6.9–8.8) | 6.3 (1.3) | 8.2 (7.7–8.2) | ||
Albumin (g/dL) | NG | 2.5 (0.3) a | 1.9 (1.9–2.0) | 2.7 (0.3) b | 2.1 (2.1–2.2) | 3.1 (0.3) b, c | 2.2 (2.0–2.5) | 3.1 (0.4) c | 2.4 (2.3–2.5) |
2.4 (0.4) | 3.5 (3.2–3.9) | 2.7 (0.6) | 3.7 (3.4–3.8) | 3.1 (0.5) | 3.9 (3.7–4.2) | 3.1 (0.6) | 4.2 (3.9–4.4) | ||
Globulins (g/dL) | NG | 2.1 (0.6) a | 1.0 (0.9–1.2) | 2.3 (0.6) a | 1.0 (1.0–1.4) | 2.6 (0.6) a, b | 1.3 (0.9–1.8) | 3.0 (0.7) b | 1.7 (1.6–1.9) |
2.1 (0.7) | 3.5 (3.1–4.0) | 2.3 (0.8) | 3.9 (3.6–3.9) | 2.7 (1.1) | 4.0 (3.6–4.4) | 3.0 (1.3) | 4.3 (4.1–4.6) | ||
Cholesterol (mg/dL) | G | 169 (86.3) a | 62 (60–68) | 199 (60.9) a | 92 (88–113) | 185 (41.1) a | 97 (73–123) | 186 (51) a | 80 (76–90) |
124 (144) | 418 (309–493) | 199 (105) | 317 (306–318) | 179 (54) | 272 (245–299) | 185 (55) | 288 (283–291) | ||
Triglycerides (mg/dL) | G | 37 (18) a | 14 (13–16) | 41 (13) a | 20 (20–23) | 43 (14) a | (12 (4–21) | 45 (14) a | 14 (14–25) |
28 (22) | 91 (65–114) | 40 (18) | 76 (67–76) | 43 (16) | 73 (64–82) | 44 (18) | 79 (66–80) | ||
Glucose (mg/dL) | G | 89 (21) a | 47 (38–56) | 90 (18) a | 49 (47–61) | 81 (21) a, b | 43 (37–53) | 77 (21) b | 36 (31–50) |
89 (26) | 132 (122–142) | 92 (23) | 135 (121–137) | 78 (33) | 131 (114–148) | 74 (32) | 122 (114–128) | ||
Urea (mg/dL) | NG | 23 (7) a | 12 (11–13) | 27 (8.7) b | 9 (8–14) | 36 (9.5) b, c | 15 (10–21) | 34 (10) c | 14 (11–18) |
20 (12) | 42 (35–48) | 27 (10) | 47 (43–48) | 35 (15) | 56 (50–62) | 34 (15) | 55 (49–56) | ||
Creatinine (mg/dL) | NG | 0.45 (0.09) a | 0.3 (0.3–0.3) | 0.59 (0.16) b | 0.4 (0.4–0.4) | 1.00 (0.30) c | 0.3 (0.0–0.5) | 1.03 (0.25) c | 0.6 (0.5–0.6) |
0.45 (0.15) | 0.7 (0.6–0.8) | 0.54 (0.26) | 1.0 (0.9–1.1) | 0.99 (0.50) | 1.6 (1.4–1.7) | 1.05 (0.43) | 1.6 (1.4–1.7) | ||
Temperature (°C) | NG | 37.9 (0.5) a | 36.7 (36.3–37) | 38.5 (0.6) b | 37.3 (37.3–37.6) | 38.7 (0.4) b, c | 37.7 (37.5–38) | 38.8 (0.4) c | 37.9 (37.9–38.1) |
38.0 (0.7) | 39 (38.8–39.2) | 38.5 (0.8) | 39.6 (39.4–39.6) | 38.7 (0.7) | 39.6 (39.3–39.7) | 38.9 (0.7) | 39.7 (39.5–39.7) | ||
Heart rate (bpm) | NG | 155 (28.4)a | 86 (64–107) | 145 (33)a | 85 (84–92) | 129 (26)a, b | 74 (58–90) | 125 (27)b | 80 (80–89) |
160 (44) | 207 (196–216) | 140 (38.5) | 200 (200–200) | 132 (28) | 185 (168–202) | 120 (40) | 180 (180–180) | ||
Breathing frequency (bpm) | NG | 30 (6.6)a | 15 (13–19) | 33 (5.9)a | 22 (22–24) | 34 (6.6)a | 20 (16–24) | 32 (7)a | 15 (15–20) |
30 (12) | 44 (41–46) | 31 (8) | 44 (40–44) | 36 (12) | 44 (44–44) | 32 (16) | 44 (44–46) |