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Table 8 Hematology and serum biochemistry of dogs with liver disorders fed diet supplemented with commercial hepatoprotectant containing silybin (EXP2)

From: Effects of silybin supplementation on nutrient digestibility, hematological parameters, liver function indices, and liver-specific mi-RNA concentration in dogs

Item

Reference value

H1

(n = 15)

H28

(n = 15)

SEM

P

WBC (× 109/L)

6.00–12.0

11.40

14.00

1.890

NSD

NEUT (× 109/L)

3.00–9.00

7.59

9.87

1.752

NSD

LYM (× 109/L)

1.00–3.60

2.60

2.37

0.362

NSD

MONO (×  109/L)

0.150–0.850

0.77

1.21

0.158

NSD

EOS (× 109/L)

0.040–0.600

0.42

0.50

0.068

NSD

BASO (× 109/L)

0.001–0.100

0.02

0.05

0.006

0.005

RBC (× 1012/L)

5.50–8.50

7.03

6.61

0.511

NSD

HEM (g/L)

15.0–19.0

175.80

127.50

11.659

NSD

HTC (%)

0.440–0.550

1.66

0.41

6.919

NSD

MCV (fL/cell)

6.0–77.0

71.14

63.95

2.255

NSD

MCH (pg/cell)

21.0–27.0

24.92

2.55

1.170

NSD

MCHC (g/L)

32.0–36.0

35.20

319.00

7.141

NSD

PLT (× 109/L)

15.0–50.0

204.80

154.00

8.354

NSD

Albumin (g/L)

25.0–44.0

37.71

33.50

1.160

0.046

ALT (U/L)

1.00–8.0

325.44

195.35

103.233

0.012

ALP (U/L)

1.00–141.0

83.25

153.10

39.726

NSD

AST (U/L)

1.00–76.0

35.03

24.09

4.879

0.016

Total protein (g/L)

54.0–75.0

65.18

58.60

2.535

NSD

Total bilirubin (μmol/L)

0.010–4.60

3.22

3.99

0.212

0.037

Fructosamine (μmol/L)

225.0–365.0

28.93

188.0

18.167

0.035

GLDH (U/L)

0.010–1.6

22.82

13.32

4.824

0.053

GLUC (mmol/L)

3.05–6.10

5.78

5.16

0.325

NSD

GGT (U/L)

0.010–7.00

23.58

7.34

7.535

0.027

Creatinine (μmol/L)

35.0–132.0

97.51

77.65

7.163

NSD

Urea (mmol/L)

3.30–8.30

7.42

3.72

0.977

0.045

Albumin / globulin ratio

0.670–1.60

1.09

0.83

0.081

NSD

Globulin (g/L)

18.0–45.0

31.39

36.25

1.807

0.008

L- amylase (g/L)

10–1650

3.77

33.50

1.16

0.050

  1. Abbreviations: H1, first day of supplementation; H28, twenty-eighth day of supplementation; WBC, White blood cells; NEUT, neutrophils; LYM, lymphocytes; MONO, monocytes; EOS, eosinophils; BASO, basophils; RBC, red blood cells; HEM, hemoglobin; HTC, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin MCHC, mean corpuscular hemoglobin concentration; PLT, platelets; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; GLDH, glutamate dehydrogenase; GLUC, glucose; GGT, gamma glutamyl transpeptidase; NSD, not statistically different
  2. P-values below 0.05 were considered statistically significant