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Table 8 Hematology and serum biochemistry of dogs with liver disorders fed diet supplemented with commercial hepatoprotectant containing silybin (EXP2)

From: Effects of silybin supplementation on nutrient digestibility, hematological parameters, liver function indices, and liver-specific mi-RNA concentration in dogs

Item Reference value H1
(n = 15)
H28
(n = 15)
SEM P
WBC (× 109/L) 6.00–12.0 11.40 14.00 1.890 NSD
NEUT (× 109/L) 3.00–9.00 7.59 9.87 1.752 NSD
LYM (× 109/L) 1.00–3.60 2.60 2.37 0.362 NSD
MONO (×  109/L) 0.150–0.850 0.77 1.21 0.158 NSD
EOS (× 109/L) 0.040–0.600 0.42 0.50 0.068 NSD
BASO (× 109/L) 0.001–0.100 0.02 0.05 0.006 0.005
RBC (× 1012/L) 5.50–8.50 7.03 6.61 0.511 NSD
HEM (g/L) 15.0–19.0 175.80 127.50 11.659 NSD
HTC (%) 0.440–0.550 1.66 0.41 6.919 NSD
MCV (fL/cell) 6.0–77.0 71.14 63.95 2.255 NSD
MCH (pg/cell) 21.0–27.0 24.92 2.55 1.170 NSD
MCHC (g/L) 32.0–36.0 35.20 319.00 7.141 NSD
PLT (× 109/L) 15.0–50.0 204.80 154.00 8.354 NSD
Albumin (g/L) 25.0–44.0 37.71 33.50 1.160 0.046
ALT (U/L) 1.00–8.0 325.44 195.35 103.233 0.012
ALP (U/L) 1.00–141.0 83.25 153.10 39.726 NSD
AST (U/L) 1.00–76.0 35.03 24.09 4.879 0.016
Total protein (g/L) 54.0–75.0 65.18 58.60 2.535 NSD
Total bilirubin (μmol/L) 0.010–4.60 3.22 3.99 0.212 0.037
Fructosamine (μmol/L) 225.0–365.0 28.93 188.0 18.167 0.035
GLDH (U/L) 0.010–1.6 22.82 13.32 4.824 0.053
GLUC (mmol/L) 3.05–6.10 5.78 5.16 0.325 NSD
GGT (U/L) 0.010–7.00 23.58 7.34 7.535 0.027
Creatinine (μmol/L) 35.0–132.0 97.51 77.65 7.163 NSD
Urea (mmol/L) 3.30–8.30 7.42 3.72 0.977 0.045
Albumin / globulin ratio 0.670–1.60 1.09 0.83 0.081 NSD
Globulin (g/L) 18.0–45.0 31.39 36.25 1.807 0.008
L- amylase (g/L) 10–1650 3.77 33.50 1.16 0.050
  1. Abbreviations: H1, first day of supplementation; H28, twenty-eighth day of supplementation; WBC, White blood cells; NEUT, neutrophils; LYM, lymphocytes; MONO, monocytes; EOS, eosinophils; BASO, basophils; RBC, red blood cells; HEM, hemoglobin; HTC, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin MCHC, mean corpuscular hemoglobin concentration; PLT, platelets; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; GLDH, glutamate dehydrogenase; GLUC, glucose; GGT, gamma glutamyl transpeptidase; NSD, not statistically different
  2. P-values below 0.05 were considered statistically significant