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Table 6 Serum Interleukins, immunoglobulins, and acute phase proteins in dogs fed diets supplemented with silybin and commercial hepatoprotectant (EXP1)

From: Effects of silybin supplementation on nutrient digestibility, hematological parameters, liver function indices, and liver-specific mi-RNA concentration in dogs

Item Unit CON
(n = 18)
HEP
(n = 18)
SIL
(n = 18)
SEM P
1 L-β (pg/ml) 10.3 13.5 14.2 3.41 NSD
IL4 (pg/ml) 382b 494a 478a 17.5 <  0.01
IL6 (pg/ml) 9409 9042 8659 322.1 NSD
IL8 (pg/ml) 22.8 114.0 52.6 29.0 NSD
IL10 (pg/ml) 12.2b 19.8ab 25.3a 1.6 < 0.01
IgA (mg/ml) 0.805 0.744 0.769 0.25 NSD
IgG (mg/ml) 9.2 10.3 10.1 0.51 NSD
IgM (mg/ml) 1.397 1.393 1.441 0.042 NSD
IgE (μg/ml) 1.794 .885 2.565 0.18 NSD
Haptoglobin (mg/ml) 0.04 0.02 0.06 0.01 NSD
CRP (ng/ml) 624 505 681 40 NSD
SAA (μg/ml) 18.8 16.1 15.8 3.70 NSD
  1. Abbreviations: CON, control group; HEP, group fed diet supplemented with commercial hepatoprotectant containing silybin; SIL, group fed diet supplemented with pure silybin; CRP, C-reactive protein; NSD, not statistically different; SA, serum amyloid-A
  2. Superscripts a,b in the same row indicate significant differences between control versus treatment groups (P < 0.05)