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Table 6 Serum Interleukins, immunoglobulins, and acute phase proteins in dogs fed diets supplemented with silybin and commercial hepatoprotectant (EXP1)

From: Effects of silybin supplementation on nutrient digestibility, hematological parameters, liver function indices, and liver-specific mi-RNA concentration in dogs

Item

Unit

CON

(n = 18)

HEP

(n = 18)

SIL

(n = 18)

SEM

P

1 L-β

(pg/ml)

10.3

13.5

14.2

3.41

NSD

IL4

(pg/ml)

382b

494a

478a

17.5

<  0.01

IL6

(pg/ml)

9409

9042

8659

322.1

NSD

IL8

(pg/ml)

22.8

114.0

52.6

29.0

NSD

IL10

(pg/ml)

12.2b

19.8ab

25.3a

1.6

< 0.01

IgA

(mg/ml)

0.805

0.744

0.769

0.25

NSD

IgG

(mg/ml)

9.2

10.3

10.1

0.51

NSD

IgM

(mg/ml)

1.397

1.393

1.441

0.042

NSD

IgE

(μg/ml)

1.794

.885

2.565

0.18

NSD

Haptoglobin

(mg/ml)

0.04

0.02

0.06

0.01

NSD

CRP

(ng/ml)

624

505

681

40

NSD

SAA

(μg/ml)

18.8

16.1

15.8

3.70

NSD

  1. Abbreviations: CON, control group; HEP, group fed diet supplemented with commercial hepatoprotectant containing silybin; SIL, group fed diet supplemented with pure silybin; CRP, C-reactive protein; NSD, not statistically different; SA, serum amyloid-A
  2. Superscripts a,b in the same row indicate significant differences between control versus treatment groups (P < 0.05)