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Table 7 Summary data of macroscopic examination for healthy Beagle dogs treated with enflicoxib orally once a week for up to 7 months

From: Long-term safety evaluation of Daxocox® tablets (enflicoxib) in dogs after weekly oral administrations for seven months

Treatment group

0X

1X

3X

5X

Dose (loading+maintenance)

(Placebo)

(8 + 4 mg/kg)

(24 + 12 mg/kg)

(40 + 20 mg/kg)

Adrenals

 Enlarged

0

0

0

1

Colon

 Dark area(s)

0

0

1

0

Epididymides

 Unilaterally Absent

0

0

1

0

Jejunum

 Abnormal colour

1

0

0

0

 Dark area(s)

0

0

0

1

 Depression(s)

1

1

0

0

Kidneys

 Abnormal Colour

0

0

0

1

Liver

 Enlarged

0

0

0

1

Lungs and Bronchi

 Abnormal colour

0

0

0

1

 Firm

0

0

0

1

 Incomplete deflation

0

0

0

1

 Pale area(s)

0

0

0

1

Lymph Node, Mesenteric

 Dark

0

0

0

1

Pituitary

 Cyst(s)

0

0

0

1

Spleen

 Abnormal Shape

0

0

0

1

 Adhesions

0

0

0

1

 Capsule Thickened

0

0

0

1

Stomach

 Dark area(s)

0

0

0

1

 Thyroids

 Small

0

0

0

1

 Uterus

 Serosal cyst(s)

0

0

0

1

  1. N = 4 animals/sex/group