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Table 7 Summary data of macroscopic examination for healthy Beagle dogs treated with enflicoxib orally once a week for up to 7 months

From: Long-term safety evaluation of Daxocox® tablets (enflicoxib) in dogs after weekly oral administrations for seven months

Treatment group 0X 1X 3X 5X
Dose (loading+maintenance) (Placebo) (8 + 4 mg/kg) (24 + 12 mg/kg) (40 + 20 mg/kg)
Adrenals
 Enlarged 0 0 0 1
Colon
 Dark area(s) 0 0 1 0
Epididymides
 Unilaterally Absent 0 0 1 0
Jejunum
 Abnormal colour 1 0 0 0
 Dark area(s) 0 0 0 1
 Depression(s) 1 1 0 0
Kidneys
 Abnormal Colour 0 0 0 1
Liver
 Enlarged 0 0 0 1
Lungs and Bronchi
 Abnormal colour 0 0 0 1
 Firm 0 0 0 1
 Incomplete deflation 0 0 0 1
 Pale area(s) 0 0 0 1
Lymph Node, Mesenteric
 Dark 0 0 0 1
Pituitary
 Cyst(s) 0 0 0 1
Spleen
 Abnormal Shape 0 0 0 1
 Adhesions 0 0 0 1
 Capsule Thickened 0 0 0 1
Stomach
 Dark area(s) 0 0 0 1
 Thyroids
 Small 0 0 0 1
 Uterus
 Serosal cyst(s) 0 0 0 1
  1. N = 4 animals/sex/group