Table 6 Organ weights mean values (g) for healthy Beagle dogs treated with enflicoxib orally once a week for up to 7 months (SD)
Treatment group | 0X | 1X | 3X | 5X | |
|---|---|---|---|---|---|
Dose (loading+maintenance) | (Placebo) | (8 + 4 mg/kg) | (24 + 12 mg/kg) | (40 + 20 mg/kg) | Pa |
Terminal body weight (kg) | 8,40 (1,44) | 8,19 (1,03) | 8,39 (1,31) | 8,31 (1,30) | ns |
Adrenal glands | 1,14 (0,48) | 1,37 (0,31) | 1,13 (0,71) | 0,91 (0,75) | ns |
Brain | 70,25 (6,49) | 72,14 (5,47) | 72,59 (4,69) | 72,05 (5,87) | ns |
Epididymides (N = 4) | 4,25 (0,98) | 3,66 (0,17) | 3,51 (0,81) | 2,81 (0,30) | ns |
Heart | 79,83 (12,48) | 77,74 (11,12) | 80,29 (9,58) | 74,69 (13,18) | ns |
Kidneys | 47,26 (12,79) | 43,69 (10,24) | 38,94 (7,01) | 42,00 (8,61) | ns |
Liver | 295,58 (51,21) | 296,02 (40,98) | 288,81 (41,54) | 303,38 (54,60) | ns |
Pituitary glands | 0,07 (0,01) | 0,06 (0,01) | 0,06 (0,01) | 0,06 (0,01) | ns |
Prostate | 7,48 (1,51) | 9,85 (4,23) | 6,60 (1,63) | 6,41 (1,67) | ns |
Spleen | 118,70 (48,95) | 123,11 (36,63) | 129,31 (51,31) | 81,52 (29,58) | ns |
Testes (N = 4) | 13,03 (1,15) | 11,92 (0,72) | 11,79 (0,75) | 14,48 (4,12) | ns |
Thymus gland | 4,95 (1,33) | 4,55 (1,28) | 5,43 (1,53) | 8,70 (2,27) | ns |
Thyroid/parathyroid glands | 0,53 (0,10) | 0,64 (0,10) | 0,54 (0,14) | 0,60 (0,11) | ns |
Ovaries (N = 4) | 0,81 (0,47) | 0,28 (0,49) | 0,52 (0,52) | 1,64 (1,31) | ns |
Uterus and Cervix (N = 4) | 3,61 (0,48) | 3,43 (0,77) | 5,75 (5,25) | 11,46 (5,74) | ns |