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Table 6 Organ weights mean values (g) for healthy Beagle dogs treated with enflicoxib orally once a week for up to 7 months (SD)

From: Long-term safety evaluation of Daxocox® tablets (enflicoxib) in dogs after weekly oral administrations for seven months

Treatment group 0X 1X 3X 5X  
Dose (loading+maintenance) (Placebo) (8 + 4 mg/kg) (24 + 12 mg/kg) (40 + 20 mg/kg) Pa
Terminal body weight (kg) 8,40 (1,44) 8,19 (1,03) 8,39 (1,31) 8,31 (1,30) ns
Adrenal glands 1,14 (0,48) 1,37 (0,31) 1,13 (0,71) 0,91 (0,75) ns
Brain 70,25 (6,49) 72,14 (5,47) 72,59 (4,69) 72,05 (5,87) ns
Epididymides (N = 4) 4,25 (0,98) 3,66 (0,17) 3,51 (0,81) 2,81 (0,30) ns
Heart 79,83 (12,48) 77,74 (11,12) 80,29 (9,58) 74,69 (13,18) ns
Kidneys 47,26 (12,79) 43,69 (10,24) 38,94 (7,01) 42,00 (8,61) ns
Liver 295,58 (51,21) 296,02 (40,98) 288,81 (41,54) 303,38 (54,60) ns
Pituitary glands 0,07 (0,01) 0,06 (0,01) 0,06 (0,01) 0,06 (0,01) ns
Prostate 7,48 (1,51) 9,85 (4,23) 6,60 (1,63) 6,41 (1,67) ns
Spleen 118,70 (48,95) 123,11 (36,63) 129,31 (51,31) 81,52 (29,58) ns
Testes (N = 4) 13,03 (1,15) 11,92 (0,72) 11,79 (0,75) 14,48 (4,12) ns
Thymus gland 4,95 (1,33) 4,55 (1,28) 5,43 (1,53) 8,70 (2,27) ns
Thyroid/parathyroid glands 0,53 (0,10) 0,64 (0,10) 0,54 (0,14) 0,60 (0,11) ns
Ovaries (N = 4) 0,81 (0,47) 0,28 (0,49) 0,52 (0,52) 1,64 (1,31) ns
Uterus and Cervix (N = 4) 3,61 (0,48) 3,43 (0,77) 5,75 (5,25) 11,46 (5,74) ns
  1. aTreated groups compared with 0X group using Williams’ test (NS: p > 0.05, * p < 0.05, ** p < 0.01)
  2. N = 4 animals/sex/group