|
Treatment group
|
0X
|
1X
|
3X
|
5X
| |
|---|
|
Dose (loading+maintenance)
|
(Placebo)
|
(8 + 4 mg/kg)
|
(24 + 12 mg/kg)
|
(40 + 20 mg/kg)
|
Pa
|
|---|
|
Terminal body weight (kg)
|
8,40 (1,44)
|
8,19 (1,03)
|
8,39 (1,31)
|
8,31 (1,30)
|
ns
|
|
Adrenal glands
|
1,14 (0,48)
|
1,37 (0,31)
|
1,13 (0,71)
|
0,91 (0,75)
|
ns
|
|
Brain
|
70,25 (6,49)
|
72,14 (5,47)
|
72,59 (4,69)
|
72,05 (5,87)
|
ns
|
|
Epididymides (N = 4)
|
4,25 (0,98)
|
3,66 (0,17)
|
3,51 (0,81)
|
2,81 (0,30)
|
ns
|
|
Heart
|
79,83 (12,48)
|
77,74 (11,12)
|
80,29 (9,58)
|
74,69 (13,18)
|
ns
|
|
Kidneys
|
47,26 (12,79)
|
43,69 (10,24)
|
38,94 (7,01)
|
42,00 (8,61)
|
ns
|
|
Liver
|
295,58 (51,21)
|
296,02 (40,98)
|
288,81 (41,54)
|
303,38 (54,60)
|
ns
|
|
Pituitary glands
|
0,07 (0,01)
|
0,06 (0,01)
|
0,06 (0,01)
|
0,06 (0,01)
|
ns
|
|
Prostate
|
7,48 (1,51)
|
9,85 (4,23)
|
6,60 (1,63)
|
6,41 (1,67)
|
ns
|
|
Spleen
|
118,70 (48,95)
|
123,11 (36,63)
|
129,31 (51,31)
|
81,52 (29,58)
|
ns
|
|
Testes (N = 4)
|
13,03 (1,15)
|
11,92 (0,72)
|
11,79 (0,75)
|
14,48 (4,12)
|
ns
|
|
Thymus gland
|
4,95 (1,33)
|
4,55 (1,28)
|
5,43 (1,53)
|
8,70 (2,27)
|
ns
|
|
Thyroid/parathyroid glands
|
0,53 (0,10)
|
0,64 (0,10)
|
0,54 (0,14)
|
0,60 (0,11)
|
ns
|
|
Ovaries (N = 4)
|
0,81 (0,47)
|
0,28 (0,49)
|
0,52 (0,52)
|
1,64 (1,31)
|
ns
|
|
Uterus and Cervix (N = 4)
|
3,61 (0,48)
|
3,43 (0,77)
|
5,75 (5,25)
|
11,46 (5,74)
|
ns
|
- aTreated groups compared with 0X group using Williams’ test (NS: p > 0.05, * p < 0.05, ** p < 0.01)
- N = 4 animals/sex/group
