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Table 5 Estimated doses for dairy cattle, steer and pig

From: Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling

Animal species

Conversion

rate

fu

Clearance

F

1-log10 reduction

MIC90 = 0.25

3-log10 reduction

MIC90 = 0.25

Dairy cattle

59%

40.6%

34.8 L/day/kg

1

4.05 mg/kg

11.1 mg/kg

Steer

64%

39.2%

16.8 L/day/kg

1

1.42 mg/kg

6.78 mg/kg

Pig

10%

66%

4.43 L/day/kg

1

0.66 mg/kg

1.45 mg/kg

  1. The conversion rate is the ENR to CIP. fu is the free (unbound) fraction. F is the absolute bioavailability. MIC90 is the 90th percentile of MIC distribution