|
Parameter (units)
|
Does
|
|---|
|
1.25
|
2.5
|
5
|
10
|
|---|
|
T1/2e (h)
|
1.65
|
1.61
|
1.32
|
1.37
|
|
Tmax (h)
|
0.25
|
0.25
|
0.18
|
0.25
|
|
AUC (μg.h/mL)
|
0.62
|
0.96
|
1.92
|
3.14
|
|
Cmax (μg/mL)
|
0.27
|
0.51
|
1.06
|
1.97
|
|
MRT (h)
|
1.57
|
2.08
|
2.13
|
2.29
|
|
Vss (L/kg)
|
4.55
|
5.06
|
5.58
|
6.68
|
|
CL (L/h.kg)
|
2.71
|
2.66
|
2.47
|
2.93
|
|
AUMC (μg.h2/mL)
|
0.72
|
1.94
|
4.64
|
7.27
|
- Cmax, maximum concentration in plasma; Tmax time to achieve maximum concentration; T1/2e, elimination half-life; AUC, area under the concentration-time curve; MRT, mean residence time; Vss, volume of distribution; CL, systemic clearance; AUMC, area under the first moment-time curve
