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Table 3 The Pharmacokinetic parameters of ENR in neutropenic thigh infected mice plasma

From: Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling

Parameter (units)

Does

1.25

2.5

5

10

T1/2e (h)

1.65

1.61

1.32

1.37

Tmax (h)

0.25

0.25

0.18

0.25

AUC (μg.h/mL)

0.62

0.96

1.92

3.14

Cmax (μg/mL)

0.27

0.51

1.06

1.97

MRT (h)

1.57

2.08

2.13

2.29

Vss (L/kg)

4.55

5.06

5.58

6.68

CL (L/h.kg)

2.71

2.66

2.47

2.93

AUMC (μg.h2/mL)

0.72

1.94

4.64

7.27

  1. Cmax, maximum concentration in plasma; Tmax time to achieve maximum concentration; T1/2e, elimination half-life; AUC, area under the concentration-time curve; MRT, mean residence time; Vss, volume of distribution; CL, systemic clearance; AUMC, area under the first moment-time curve
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BMC Veterinary Research

ISSN: 1746-6148

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