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Table 3 The Pharmacokinetic parameters of ENR in neutropenic thigh infected mice plasma

From: Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling

Parameter (units) Does
1.25 2.5 5 10
T1/2e (h) 1.65 1.61 1.32 1.37
Tmax (h) 0.25 0.25 0.18 0.25
AUC (μg.h/mL) 0.62 0.96 1.92 3.14
Cmax (μg/mL) 0.27 0.51 1.06 1.97
MRT (h) 1.57 2.08 2.13 2.29
Vss (L/kg) 4.55 5.06 5.58 6.68
CL (L/h.kg) 2.71 2.66 2.47 2.93
AUMC (μg.h2/mL) 0.72 1.94 4.64 7.27
  1. Cmax, maximum concentration in plasma; Tmax time to achieve maximum concentration; T1/2e, elimination half-life; AUC, area under the concentration-time curve; MRT, mean residence time; Vss, volume of distribution; CL, systemic clearance; AUMC, area under the first moment-time curve