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Table 2 The CIP concentration (μg/mL) in neutropenic infected mice following single s.c injection

From: Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling

Time (h)

Dosage regimen (mg/kg)

 

1.25

2.5

5

10

0.083

–

–

–

–

0.167

–

0.029 ± 0.009

0.031 ± 0.011

0.037 ± 0.014

0.25

0.019 ± 0.007

0.037 ± 0.011

0.057 ± 0.019

0.09 ± 0.027

0.5

0.009 ± 0.002

0.019 ± 0.004

0.026 ± 0.009

0.056 ± 0.017

0.75

–

0.007 ± 0.002

0.009 ± 0.002

0.029 ± 0.009

1

–

–

–

0.017 ± 0.004

2

–

–

–

0.006 ± 0.001