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Table 1 CC50 values for vehicle (DMSO) and betulin

From: High cytotoxicity of betulin towards fish and murine fibroblasts: Is betulin safe for nonneoplastic cells?

cell line DMSO (MTT) betulin
MTT NRU SRB
24 h 48 h 72 h 24 h 48 h 72 h 24 h 48 h 72 h 24 h 48 h 72 h
NIH/3T3 2.989
± 0.159
2.374
± 0.395
1.635
± 0.423
1.532
± 0.005
1.585
± 0.64
1.853
± 0.647
˃15.625 7.329
± 2.942
12.954
± 2.942
10.87
± 7.338
4.051
± 1.242
3.756
± 0.572
BF-2 5.031
± 0.423
4.434
± 0.717
4.794
± 0.337
3.394
± 0.903
2.751
± 1.051
3.021
± 1.034
27.615
± 9.006
16.462
± 3.599
14.516
± 3.41
>31.25 >31.25 >31.25
  1. DMSO concentrations in %, betulin concentrations in µg/mL. CC50 (50 % cytotoxic concentration) values expressed as means ± SD (standard deviation) for n = 3 independent experiments. CC50 values were calculated using the Quest Graph™ ED50 Calculator (AAT Bioquest, Inc.)