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Table 1 Molecular characteristics of H5 isolates associated with pathogenicity

From: Genetic characterization of an H5N6 avian influenza virus with multiple origins from a chicken in southern China, October 2019

Virus Subtype Clade Pathotype HA NA PB2 PB1
Cleavage site RBS stalk deletion 274 294 23 627 473
  186 226–228       
A/Anhui/1/2005 H5N1 2.3.4 HPAI RERRRKRGLF N QSG YES H N T E V
A/Hunan/1/2009 H5N1 2.3.4.1 HPAI RERRRKRGLF N QSG YES H N T E V
A/goose/Yunnan/6193/2006 H5N1 2.3.4.2 HPAI RERRRKRGLF N QSG YES H N T E V
A/avian/Hong_Kong/2372/2007 H5N1 2.3.4.3 HPAI RERRRKRGLF N QSG YES H N T E V
A/duck/Hunan/2.06_YYGK78J3-OC/2018 H5N6 2.3.4.4 HPAI RERRRKRGLF N QRG NO H N T E V
A/chicken/Dongguan/1101/2019 H5N6 2.3.4.4 HPAI RERRRKRGLF N QRG YES H N T E V
A/muscovy duck/Japan/AQ-HE30-77C2/ 2018 H5N6 2.3.4.4 HPAI RERRRKRGLF N QRG YES H N T E V