Fig. 2

Development of mucocutaneous nasal lesions over a 3-months follow-up period. a At the initial presentation, the left nostril was markedly swollen and ulcerative, deformed, hypo- to depigmented, and revealed a clear nasal discharge. A nasal stertor was noted from that side of the nose (b) Two weeks (16 days) after initiating treatment with itraconazole, the swelling and ulceration around the left nostril was reduced, with granulation tissue covering the lesion. The dog also no longer had a stertorous breathing. c Six weeks later (day 64), the left nostril appeared nearly healed with only a small (approximately 1 mm) rim of depigmentation and granulation tissue around the left nostril. The remainder of the nares was scarred and slightly deformed, but the pigmentation had returned. d Four weeks later (day 91), the nasal mucocutaneous lesion had healed with black pigment filling in and around the left nostril, where a one-mm rim of mild scarring was still noticeable