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Table 2 General Linear Models analysis (with ranked data) on the effect of MAC, gas, sedative, individual, and the interactions (of MAC x gas, MAC x sedative, gas x sedative, only shown if significant) in chickens (n = 10) undergoing inhalation anaesthesia with isoflurane and sevoflurane alone or combined with NaCl solution (0.25 ml/kg), butorphanol (1 mg/kg) or medetomidine (0.1 mg/kg) in a cross-over randomized study, obtaining repeated measurements per individual; gas being isoflurane and sevoflurane, and sedatives being butorphanol and medetomidine. Significant interactions set in bold

From: Effects of isoflurane and sevoflurane alone and in combination with butorphanol or medetomidine on the bispectral index in chickens

Dependent variable

Covariables /Cofactors

MAC

Gas

Sedative

Interaction(s)

Individual

HR

P < 0.001

P = 0.031

P < 0.001

(Sedative x MAC)

P < 0.001

P < 0.001

NIBP

P < 0.001

P = 0.183

P = 0.036

(Sedative x Gas)

P = 0.012

(Sedative x MAC)

P = 0.010

(Gas x MAC)

P = 0.001

P < 0.001

VAS

P < 0.001

P = 0.089

P < 0.001

(Sedative x MAC)

P = 0.016

P = 0.099

BISpre

P < 0.001

P = 0.595

P = 0.615

n.s.

P = 0.001

BISpost

P < 0.001

P = 0.685

P = 0.468

n.s.

P = 0.015

BISdiff

P < 0.001

P = 0.177

P = 0.133

n.s.

P = 0.159

SR

P < 0.001

P = 0.598

P = 0.854

n.s.

P = 0.495

  1. Abbreviations: MAC minimum anaesthetic concentration multiple, HR heart rate, NIBP non-invasive blood pressure, BISpre bispectral index before stimulus, BISpost bispectral index after stimulus, BISdiff difference between BISpre and BISpost, SR suppression ratio, VAS visual analog scale, n.s. not shown