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Table 2 General Linear Models analysis (with ranked data) on the effect of MAC, gas, sedative, individual, and the interactions (of MAC x gas, MAC x sedative, gas x sedative, only shown if significant) in chickens (n = 10) undergoing inhalation anaesthesia with isoflurane and sevoflurane alone or combined with NaCl solution (0.25 ml/kg), butorphanol (1 mg/kg) or medetomidine (0.1 mg/kg) in a cross-over randomized study, obtaining repeated measurements per individual; gas being isoflurane and sevoflurane, and sedatives being butorphanol and medetomidine. Significant interactions set in bold

From: Effects of isoflurane and sevoflurane alone and in combination with butorphanol or medetomidine on the bispectral index in chickens

Dependent variable Covariables /Cofactors
MAC Gas Sedative Interaction(s) Individual
HR P < 0.001 P = 0.031 P < 0.001 (Sedative x MAC)
P < 0.001
P < 0.001
NIBP P < 0.001 P = 0.183 P = 0.036 (Sedative x Gas)
P = 0.012
(Sedative x MAC)
P = 0.010
(Gas x MAC)
P = 0.001
P < 0.001
VAS P < 0.001 P = 0.089 P < 0.001 (Sedative x MAC)
P = 0.016
P = 0.099
BISpre P < 0.001 P = 0.595 P = 0.615 n.s. P = 0.001
BISpost P < 0.001 P = 0.685 P = 0.468 n.s. P = 0.015
BISdiff P < 0.001 P = 0.177 P = 0.133 n.s. P = 0.159
SR P < 0.001 P = 0.598 P = 0.854 n.s. P = 0.495
  1. Abbreviations: MAC minimum anaesthetic concentration multiple, HR heart rate, NIBP non-invasive blood pressure, BISpre bispectral index before stimulus, BISpost bispectral index after stimulus, BISdiff difference between BISpre and BISpost, SR suppression ratio, VAS visual analog scale, n.s. not shown