Fig. 5

Chemokine ligand 2 (CCL2), chemokine ligand 3 (CCL3), chemokine ligand 5 (CCL5) and chemokine ligand 11 (CCL11) concentrations in the synovial fluid of middle carpal joints (MCJ) and tarsocrural joints (TCJ) following IL-1β-induced synovitis or intra-articular lavage. CCL2 was increased from baseline from 6 to 24 h following synovitis and was greater in synovitis MCJ as compared to contralateral MCJ at 6 and 24 h post-synovitis induction (a). Following lavage, CCL2 was increased from baseline from 6 to 12 h but did not differ from contralateral TCJ (b). CCL3 was increased from baseline and was greater in synovitis MCJ compared to contralateral MCJ at 6 h post-synovitis induction (c). CCL3 was less in the lavage TCJ as compared to the contralateral TCJ at baseline but otherwise had no response to lavage (d). Following synovitis, CCL5 was increased from baseline at 6, 12, and 72 h and was greater compared to the contralateral MCJ at 6, 72, and 168 h (e). CCL5 did not change in response to lavage (f). CCL11 was increased from baseline from 6 to 72 h following synovitis and was greater in synovitis MCJ than contralateral MCJ from 6 to 48 h (g). CCL11 was increased from baseline at 6 and 12 h post-lavage and did not differ from contralateral TCJ at any time. An asterisk indicates a difference from baseline, and a triangle indicates a difference from the contralateral limb at the same time point. Graphed values are marginal means +/− SEM