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Table 1 Median (range) biomarker values by timepoint after bite in envenomated dogs and healthy controls

From: Serial serum creatinine, SDMA and urinary acute kidney injury biomarker measurements in dogs envenomated by the European adder (Vipera berus)

  Control T1
(presentation)
T2
(12 h)
T3
(24 h)
T4
(36 h)
T5
(14 days)
sCr
(μmol/L)
88.4
(44.2–150.3)
70.7
(53–106)
61.88
(53–97.2)
66.3
(44.2–88.4)
70.7
(44.2–97.2)
79.6
(53–123.8)
SDMA
(μmol/L)
0.54
(0.35–0.74)
0.5
(0.35–0.64)
0.47
(0.25–0.64)
0.45
(0.25–0.64)
0.4
(0.25–0.69)
0.54
(0.3–0.84)
uKIM-1/uCr
(ng/mg)
0.13
(0.013–0.36)
  0.13
(0.001–0.2)
0.15
(0.002–0.32)
0.20
(0.008–0.35)
0.14
(0.03–0.25)
uOPN/uCr
(ng/mg)
1.86
(0.13–4.2)
  2.54
(0.08–7.96)
5.22
(0.22–24.87)
6.34
(0.5–31.86)
1.88
(0.26–15.46)
uCysC/uCr
(ng/mg)
0.95
(0.16–3.74)
  0.66
(0.22–1.43)
0.57
(0.17–2.94)
0.56
(0.24–1.78)
0.58
(0.17–2.39)
uNGAL/uCr
(ng/mg)
0.21
(0.02–2.94)
  2.8
(0.1–15.78)
2.1
(0.07–3.02)
2.62
(0.09–21.66)
0.28
(0.03–23.3)
uMCP-1/uCr
(ng/mg)
0.46
(0.05–1.97)
  0.8
(0.15–5.44)
0.78
(0.23–7.24)
0.88
(0.27–5.58)
0.6
(0.09–6.14)
uGGT/uCr
(U/g)
15.4
(0.95–75.26)
  30.14
(3.96–83.44)
21.6
(0–85.65)
28.52
(9–120.5)
18.27
(0–48.83)
uALB/uCr
mg/g
0.005
(0.002–6)
32/34 (94.1%)
< LOQ*
  0.019
(0.03–289)
9/16 (56%)
< LOQ
0.036
(0.004–116)
16/25 (64%)
<LOQ
0.025
(0.01–175)
17/22 (77%)
< LOQ
0.007
(0.004–124)
16/19 (84%)
< LOQ
uIL-8/uCr
(ng/mg)
0.06
(0.02–0.9)
18/34 (52.9%)
< LOQ**
  0.08
(0.02–0.29)
10/16 (62.5%) < LOQ
0.14
(0.03–1.62)
21/24 (87.5%)
< LOQ
0.14
(0.05–0.79)
18/22 (81.8%) < LOQ
0.07
(0.03–3.37)
14/20 (70%)
< LOQ
uALP/uCr
(U/g)
100% < LOQ***   100% < LOQ 100% < LOQ 96% < LOQ 100% < LOQ
  1. * Limit of quantification (LOQ) = 9.6 ng/mL, **LOQ = 0.07 ng/mL, *** LOQ = 10 U/L