Table 1 Relevant laboratory values during treatment demonstrating criteria for NS developing 328 days after starting toceranib phosphate

Days post-presentation (Days post-toceranib phosphate start)

98 (0)

120 (22)

182 (84)

262 (164)

331 (233)

426 (328)

434 (336)

449 (351)

477 (379)

Albumin (g/dL) ref.: 2.9–4.0

2.8

2.6

3.2

3.2

2.7

< 1.5

1.8

2.6

2.8

Cholesterol (mg/dL) ref.: 133–338

353

317

274

359

233

378

x

x

x

UPC ref.: < 0.5

6.48

2.03

x

x

x

3.79

2.15

1.7

0.84

Edema

–

–

–

–

–

+

–

–

–

BUN (mg/dL) ref.: 8–28

12

x

16

11

14

21

20

18

17

Creatinine (mg/dL) ref.: 0.6–1.6

0.6

x

0.9

1.0

1.1

1.1

0.9

0.9

0.9